Unmet medical needs in chronic, non-communicable inflammatory skin diseases

H Ujiie, D Rosmarin, MP Schön, S Ständer… - Frontiers in …, 2022 - frontiersin.org
An estimated 20–25% of the population is affected by chronic, non-communicable
inflammatory skin diseases. Chronic skin inflammation has many causes. Among the most …

Dipeptidyl peptidase 4 inhibitors and their potential immune modulatory functions

S Shao, QQ Xu, X Yu, R Pan, Y Chen - Pharmacology & therapeutics, 2020 - Elsevier
Abstract Dipeptidyl peptidase 4 (DPP4) inhibitors (DPP4is) are oral anti-diabetic drugs
(OADs) for the treatment of type 2 diabetes mellitus (T2DM) through inhibiting the …

Bullous pemphigoid: trigger and predisposing factors

F Moro, L Fania, JLM Sinagra, A Salemme, G Di Zenzo - Biomolecules, 2020 - mdpi.com
Bullous pemphigoid (BP) is the most frequent autoimmune subepidermal blistering disease
provoked by autoantibodies directed against two hemidesmosomal proteins: BP180 and …

[HTML][HTML] A systematic review of drug-associated bullous pemphigoid

MJ Verheyden, A Bilgic, DF Murrell - Acta dermato-venereologica, 2020 - ncbi.nlm.nih.gov
Bullous pemphigoid is an autoimmune subepithelial disease characterised by pruritus
followed by urticarial plaques and finally bullae on the skin and mucosa. Drug-associated …

Dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid

K Tasanen, O Varpuluoma, W Nishie - Frontiers in immunology, 2019 - frontiersin.org
Bullous pemphigoid (BP) is an organ-specific autoantibody-mediated blistering skin disease
that mainly affects the elderly. Typical clinical features include the widespread blisters, often …

Association of dipeptidyl peptidase 4 inhibitor use with risk of bullous pemphigoid in patients with diabetes

SG Lee, HJ Lee, MS Yoon, DH Kim - JAMA dermatology, 2019 - jamanetwork.com
Importance Recent studies suggest that dipeptidyl peptidase 4 (DPP-4) inhibitors are
associated with an increased risk of developing bullous pemphigoid (BP). Population-based …

Association between medication use and bullous pemphigoid: a systematic review and meta-analysis

SD Liu, WT Chen, CC Chi - JAMA dermatology, 2020 - jamanetwork.com
Importance The association between the use of medications and the development of bullous
pemphigoid (BP) is unclear. Objective To assess the associations between previous …

Emerging role of dipeptidyl peptidase-4 in autoimmune disease

J Huang, X Liu, Y Wei, X Li, S Gao, L Dong… - Frontiers in …, 2022 - frontiersin.org
Dipeptidyl-peptidase IV (DPP4), originally identified as an aminopeptidase in 1960s, is an
ubiquitously expressed protease presented as either a membrane-bound or soluble form …

Higher frequency of dipeptidyl peptidase-4 inhibitor intake in bullous pemphigoid patients than in the French general population

M Plaquevent, F Tétart, L Fardet… - Journal of Investigative …, 2019 - Elsevier
Dipeptidyl peptidase-4 inhibitors have been suspected to induce bullous pemphigoid (BP).
The objective of this study was to compare the observed frequency of gliptin intake in a large …

Targeted therapies for autoimmune bullous diseases: current status

KT Amber, R Maglie, F Solimani, R Eming, M Hertl - Drugs, 2018 - Springer
Autoimmune bullous skin disorders are rare but meaningful chronic inflammatory diseases,
many of which had a poor or devastating prognosis prior to the advent of …