CD40, a novel immunomodulatory cancer therapy target, is expressed by B cells,
macrophages, and dendritic cells (DCs) and mediates cytotoxic T cell priming through the …

Despite advances in cancer treatment, hepatocellular carcinoma (HCC), the most common
form of liver cancer, remains a major public health problem worldwide. The immune …

The combination of radiotherapy/chemoradiotherapy and immune checkpoint blockade can
result in poor outcomes in patients with locally advanced head and neck squamous cell …

Hepatocellular carcinoma (HCC) is associated with increased soluble CD40 levels. This
study aimed to investigate CD40's role in liver tumor progression. CD40 levels were …

Onco-virotherapy is an emergent treatment for cancer based on viral vectors. The
therapeutic activity is based on two different mechanisms including tumor-specific oncolysis …

Introduction There is a need for new therapies that can enhance response rates and
broaden the number of cancer indications where immunotherapies provide clinical benefit …

BRCA1 and BRCA2 mutations significantly increase the risk of breast and ovarian cancers
(OC) by affecting crucial cellular processes such as cell cycle regulation, DNA repair, and …

The dynamic interplay between cellular immunity and tumor cells is essential in cancer
advancement and response to therapy. This updated, comprehensive review examines the …

Despite some success in other cancer types, the results of combining radiotherapy/
chemoradiotherapy and immune checkpoint blockade have been disappointing in patients …

Cadmium (Cd) is classified as a human carcinogen with widespread environmental
exposure, correlating with increased incidences of lung and renal cancers. The mechanism …