Embryogenesis involves orchestrated processes of cell proliferation and differentiation. The
mammalian Hes basic helix-loop-helix repressor genes play central roles in these …

Hes and Hey genes are the mammalian counterparts of the Hairy and Enhancer-of-split type
of genes in Drosophila and they represent the primary targets of the Delta–Notch signaling …

MicroRNAs (miRNAs) are endogenous noncoding RNAs, which negatively regulate gene
expression. To determine genomewide miRNA DNA copy number abnormalities in cancer …

Expression of the Notch effector gene Hes1 is required for maintenance of neural
progenitors in the embryonic brain, but persistent and high levels of Hes1 expression inhibit …

In the developing mammalian nervous system, neural progenitor cells first express the Notch
effector Hes1 at variable levels and then proneural genes and Notch ligands in salt-and …

Cellular quiescence is a reversible non-proliferating state. The reactivation of 'sleep-
like'quiescent cells (eg fibroblasts, lymphocytes and stem cells) into proliferation is crucial for …

Estrogen receptor β (ERβ) is the predominant ER in the colorectal epithelium. Compared
with normal colon tissue, ERβ expression is reduced in colorectal cancer. Our hypothesis is …

The developing central nervous system is partitioned into compartments by boundary cells,
which have different properties than compartment cells, such as forming neuron-free zones …

Estrogens, which are stimulators of growth of both the normal breast and malignant breast,
mediate their effects through two estrogen receptors (ER), namely ERα and ERβ. ERα …

Unlike conventional T cells, which are exported from the thymus as naive cells and acquire
effector functions upon antigen encounter in the periphery, a subset of γδ T cells …