This article is part of a Special Issue “Puberty and Adolescence”. This paper examines
consistency of effects of pubertal timing (going through puberty earlier, later or at the same …

MKRN3 mutations represent the most common genetic cause of central precocious puberty
(CPP) but associations between genotype and clinical features have not been extensively …

Background Increased numbers of neutrophils are reported in the airways of patients with
severe asthma. It is not clear if they contribute to the lack of control and severity. There are …

Background: Scoliosis progression during adolescence is closely related to patient maturity.
Maturity has various indicators, including chronological age, height and weight changes …

Puberty is the period of development when sexual, reproductive maturity is reached. The
span of puberty covers the approximate ages of 9–15 in girls and 10–16 in boys. Why is this …

The complex networks of nutritional, cellular, paracrine, and endocrine factors are closely
related with pubertal growth and epiphyseal fusion. Important influencing factors include …

Context: A subset of patients diagnosed with idiopathic hypogonadotropic hypogonadism
(IHH) later achieves activation of their hypothalamic-pituitary-gonadal axis with …

This article is part of a Special Issue “Puberty and Adolescence”. Historical records reveal a
secular trend toward earlier onset of puberty in both males and females, often attributed to …

Background Few studies have explored the trends in central precocious puberty (CPP) in
Asian populations. This study assessed the prevalence and annual incidence of CPP …

Central precocious puberty (CPP) is defined as an early pubertal development that occurs
before the age of 9 years in boys and 8 years in girls. It results from premature activation of …