Alzheimer's disease and metabolic syndrome: A link from oxidative stress and inflammation to neurodegeneration

E Rojas‐Gutierrez, G Muñoz‐Arenas, S Treviño… - Synapse, 2017 - Wiley Online Library
Alzheimer's disease (AD) is the most common cause of dementia and one of the most
important causes of morbidity and mortality among the aging population. AD diagnosis is …

Role of adiposity-driven inflammation in depressive morbidity

L Capuron, J Lasselin, N Castanon - Neuropsychopharmacology, 2017 - nature.com
Depression and metabolic disorders, including overweight and obesity, appear tightly
interrelated. The prevalence of these conditions is concurrently growing worldwide, and both …

Inside the diabetic brain: Insulin resistance and molecular mechanism associated with cognitive impairment and its possible therapeutic strategies

BJ Dutta, S Singh, S Seksaria, GD Gupta… - Pharmacological …, 2022 - Elsevier
Type 2 diabetes mellitus (T2DM) the most prevalent metabolic disease that has evolved into
a major public health issue. Concerning about its secondary complications, a growing body …

DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress

B Wang, C Wu, Z Chen, P Zheng, Y Liu… - Acta pharmacologica …, 2021 - nature.com
Abstract DL-3-n-Butylphthalide (DL-NBP), a small molecular compound extracted from the
seeds of Apium graveolens Linn (Chinese celery), has been shown to exert neuroprotective …

Gut metabolite TMAO induces synaptic plasticity deficits by promoting endoplasmic reticulum stress

M Govindarajulu, PD Pinky, I Steinke… - Frontiers in Molecular …, 2020 - frontiersin.org
Dysbiosis of gut microbiota is strongly associated with metabolic diseases including
diabetes mellitus, obesity, and cardiovascular disease. Recent studies indicate that …

Type 2 diabetes, cognition, and dementia in older adults: toward a precision health approach

B Cholerton, LD Baker, TJ Montine… - Diabetes Spectrum, 2016 - Am Diabetes Assoc
IN BRIEF There has been a concurrent dramatic rise in type 2 diabetes and dementia in the
United States, and type 2 diabetes shares common genetic and environmental risk factors …

Role of neuroinflammation in the emotional and cognitive alterations displayed by animal models of obesity

N Castanon, G Luheshi, S Layé - Frontiers in neuroscience, 2015 - frontiersin.org
Obesity is associated with a high prevalence of mood disorders and cognitive dysfunctions
in addition to being a significant risk factor for important health complications such as …

PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-β generation by reducing β-secretase in an Alzheimer's disease model

L Katsouri, YM Lim, K Blondrath… - Proceedings of the …, 2016 - National Acad Sciences
Current therapies for Alzheimer's disease (AD) are symptomatic and do not target the
underlying Aβ pathology and other important hallmarks including neuronal loss. PPARγ …

HMG-CoA reductase inhibitors bind to PPARα to upregulate neurotrophin expression in the brain and improve memory in mice

A Roy, M Jana, M Kundu, GT Corbett, SB Rangaswamy… - Cell metabolism, 2015 - cell.com
Neurotrophins are important for neuronal health and function. Here, statins, inhibitors of
HMG-CoA reductase and cholesterol lowering drugs, were found to stimulate expression of …

Cognitive dysfunction: a growing link between diabetes and Alzheimer's disease

K Jash, P Gondaliya, P Kirave… - Drug development …, 2020 - Wiley Online Library
Diabetes mellitus (DM) is a gradually rising metabolic disease which is currently affecting
millions of people worldwide. Diabetes is associated with various complications like …