Tumor microenvironment: Challenges and opportunities in targeting metastasis of triple negative breast cancer

KGK Deepak, R Vempati, GP Nagaraju… - Pharmacological …, 2020 - Elsevier
Triple negative breast cancer (TNBC) is most aggressive subtype of breast cancers with high
probability of metastasis as well as lack of specific targets and targeted therapeutics. TNBC …

Triple negative breast cancer: emerging therapeutic modalities and novel combination therapies

A Lee, MBA Djamgoz - Cancer treatment reviews, 2018 - Elsevier
Triple negative breast cancer (TNBC) is a complex and aggressive subtype of breast cancer
which lacks oestrogen receptors, progesterone receptors and HER2 amplification, thereby …

Organotropism: new insights into molecular mechanisms of breast cancer metastasis

W Chen, AD Hoffmann, H Liu, X Liu - NPJ precision oncology, 2018 - nature.com
Metastasis accounts for 90% of breast cancer mortality. Despite the significant progress
made over the past decade in cancer medicine our understanding of metastasis remains …

Triple-negative breast cancer: is there a treatment on the horizon?

H Yao, G He, S Yan, C Chen, L Song, TJ Rosol… - …, 2016 - pmc.ncbi.nlm.nih.gov
Triple-negative breast cancer (TNBC), which accounts for 15–20% of all breast cancers,
does not express estrogen receptor (ER) or progesterone receptor (PR) and lacks human …

[HTML][HTML] Breast cancer subtypes predict the preferential site of distant metastases: a SEER based study

Q Wu, J Li, S Zhu, J Wu, C Chen, Q Liu, W Wei… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Results A total of 243,896 patients, including 226,451 cases in control groups were
identified. Bone metastasis was found in 8848 cases, compared with 1,000 brain metastasis …

Brain metastases in newly diagnosed breast cancer: a population-based study

AM Martin, DN Cagney, PJ Catalano, LE Warren… - JAMA …, 2017 - jamanetwork.com
Importance Population-based estimates of the incidence and prognosis of brain metastases
at diagnosis of breast cancer are lacking. Objective To characterize the incidence …

Breast cancer brain metastases: biology and new clinical perspectives

I Witzel, L Oliveira-Ferrer, K Pantel, V Müller… - Breast cancer …, 2016 - Springer
Because of improvements in the treatment of patients with metastatic breast cancer, the
development of brain metastases (BM) has become a major limitation of life expectancy and …

Metastatic breast cancer: the potential of miRNA for diagnosis and treatment monitoring

A McGuire, JAL Brown, MJ Kerin - Cancer and metastasis reviews, 2015 - Springer
Breast cancer affects approximately 12% women worldwide and results in 14% of all cancer-
related fatalities. Breast cancer is commonly categorized into one of four main subtypes …

New insights into the correlations between circulating tumor cells and target organ metastasis

Q Zhan, B Liu, X Situ, Y Luo, T Fu, Y Wang… - … and Targeted Therapy, 2023 - nature.com
Organ-specific metastasis is the primary cause of cancer patient death. The distant
metastasis of tumor cells to specific organs depends on both the intrinsic characteristics of …

Breast cancer subtypes predispose the site of distant metastases

A Soni, Z Ren, O Hameed, D Chanda… - American journal of …, 2015 - academic.oup.com
Objectives: The distant organs to which breast cancer preferentially metastasizes are of
significant clinical importance. Methods: We explored the relationship between the …