Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function

BLM Hogan, CE Barkauskas, HA Chapman, JA Epstein… - Cell stem cell, 2014 - cell.com
Respiratory disease is the third leading cause of death in the industrialized world.
Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of …

Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies?

D Jonigk, C Werlein, T Acker, M Aepfelbacher… - Virchows Archiv, 2022 - Springer
The use of autopsies in medicine has been declining. The COVID-19 pandemic has
documented and rejuvenated the importance of autopsies as a tool of modern medicine. In …

Drug-delivery nanoplatform with synergistic regulation of angiogenesis–osteogenesis coupling for promoting vascularized bone regeneration

Y Li, J Zhu, X Zhang, Y Li, S Zhang… - … Applied Materials & …, 2023 - ACS Publications
It has been confirmed that substantial vascularization is an effective strategy to heal large-
scale bone defects in the field of bone tissue engineering. The local application of …

Postnatal development of cerebrovascular structure and the neurogliovascular unit

V Coelho‐Santos, AY Shih - Wiley Interdisciplinary Reviews …, 2020 - Wiley Online Library
The unceasing metabolic demands of brain function are supported by an intricate three‐
dimensional network of arterioles, capillaries, and venules, designed to effectively distribute …

Recent advances in the mechanisms of lung alveolarization and the pathogenesis of bronchopulmonary dysplasia

DMG Silva, C Nardiello, A Pozarska… - American Journal of …, 2015 - journals.physiology.org
Alveolarization is the process by which the alveoli, the principal gas exchange units of the
lung, are formed. Along with the maturation of the pulmonary vasculature, alveolarization is …

Inorganic agents for enhanced angiogenesis of orthopedic biomaterials

M Šalandová, IAJ van Hengel… - Advanced …, 2021 - Wiley Online Library
Aseptic loosening of a permanent prosthesis remains one of the most common reasons for
bone implant failure. To improve the fixation between implant and bone tissue as well as …

Effects of nintedanib on the microvascular architecture in a lung fibrosis model

M Ackermann, YO Kim, WL Wagner, D Schuppan… - Angiogenesis, 2017 - Springer
Nintedanib, a tyrosine kinase inhibitor approved for the treatment of idiopathic pulmonary
fibrosis, has anti-fibrotic, anti-inflammatory, and anti-angiogenic activity. We explored the …

Vascular niche in lung alveolar development, homeostasis, and regeneration

A Mammoto, T Mammoto - Frontiers in bioengineering and …, 2019 - frontiersin.org
Endothelial cells (ECs) constitute small capillary blood vessels and contribute to delivery of
nutrients, oxygen and cellular components to the local tissues, as well as to removal of …

Regeneration of the pulmonary vascular endothelium after viral pneumonia requires COUP-TF2

G Zhao, AI Weiner, KM Neupauer… - Science …, 2020 - science.org
Acute respiratory distress syndrome is associated with a robust inflammatory response that
damages the vascular endothelium, impairing gas exchange. While restoration of …

The role of vasculature and angiogenesis in respiratory diseases

M Ackermann, C Werlein, E Plucinski, S Leypold… - Angiogenesis, 2024 - Springer
In European countries, nearly 10% of all hospital admissions are related to respiratory
diseases, mainly chronic life-threatening diseases such as COPD, pulmonary hypertension …