Covering: up to January 2017 Cytochrome P450 enzymes (P450s) are some of the most
exquisite and versatile biocatalysts found in nature. In addition to their well-known roles in …

Daidzein and genistein are two major components of soy isoflavones. They exist abundantly
in plants and possess multiple bioactivities. In contrast, ortho-hydroxydaidzein (OHD) and …

Cytochrome P450 enzymes are highly diversified biocatalysts associated with steroid
biosynthesis, xenobiotic metabolism, biosynthesis of natural products, and industrial …

Mycobacterium tuberculosis (Mtb) codes for 20 cytochrome P450 enzymes (CYPs),
considered potential drug-targets due to their essential roles in bacterial viability and host …

Selective oxidation reactions represent a challenging task for conventional organic
chemistry. Whole-cell biocatalysis provides a very convenient, easy to apply method to carry …

Our previous study showed that CYP105D7, a substrate-promiscuous P450, catalyzes the
hydroxylation of 1-deoxypentalenic acid, diclofenac, naringenin, and compactin. In this …

Soy isoflavones are naturally occurring phytochemicals, which are biotransformed into
functional derivatives through oxidative and reductive metabolic pathways of diverse …

Flavanones have a wide range of pharmacological activities. Previously, we showed that
CYP105D7, a cytochrome P450, from Streptomyces avermitilis can catalyze hydroxylation of …

Bioconversion using microorganisms and their enzymes is an important tool in many
industrial fields. The discovery of useful new microbial enzymes contributes to the …

Objectives To investigate the regio-selective demethylation of papaverine by CYP105D1
and develop a whole-cell biocatalytic system for the preparative synthesis of 6-O-demethyl …