Defining the risk of SARS-CoV-2 variants on immune protection

MM DeGrace, E Ghedin, MB Frieman, F Krammer… - Nature, 2022 - nature.com
The global emergence of many severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) variants jeopardizes the protective antiviral immunity induced after infection or …

Antibody-mediated neutralization of SARS-CoV-2

H Gruell, K Vanshylla, T Weber, CO Barnes, C Kreer… - Immunity, 2022 - cell.com
Neutralizing antibodies can block infection, clear pathogens, and are essential to provide
long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies …

[PDF][PDF] mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant

WF Garcia-Beltran, KJS Denis, A Hoelzemer, EC Lam… - Cell, 2022 - cell.com
Recent surveillance has revealed the emergence of the SARS-CoV-2 Omicron variant (BA.
1/B. 1.1. 529) harboring up to 36 mutations in spike protein, the target of neutralizing …

Imprinted antibody responses against SARS-CoV-2 Omicron sublineages

YJ Park, D Pinto, AC Walls, Z Liu, A De Marco… - Science, 2022 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages carry
distinct spike mutations resulting in escape from antibodies induced by previous infection or …

Viral loads of Delta-variant SARS-CoV-2 breakthrough infections after vaccination and booster with BNT162b2

M Levine-Tiefenbrun, I Yelin, H Alapi, R Katz… - Nature medicine, 2021 - nature.com
The effectiveness of the coronavirus disease 2019 (COVID-19) BNT162b2 vaccine in
preventing disease and reducing viral loads of breakthrough infections (BTIs) has been …

[PDF][PDF] mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron

M Gagne, JI Moliva, KE Foulds, SF Andrew, BJ Flynn… - Cell, 2022 - cell.com
SARS-CoV-2 Omicron is highly transmissible and has substantial resistance to
neutralization following immunization with ancestral spike-matched vaccines. It is unclear …

Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B. 1.1. 529

T Zhou, L Wang, J Misasi, A Pegu, Y Zhang, DR Harris… - Science, 2022 - science.org
The rapid spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.
1.1. 529 (Omicron) variant and its resistance to neutralization by vaccinee and convalescent …

Characterization of the significant decline in humoral immune response six months post‐SARS‐CoV‐2 mRNA vaccination: a systematic review

KI Notarte, I Guerrero‐Arguero… - Journal of medical …, 2022 - Wiley Online Library
Accumulating evidence shows a progressive decline in the efficacy of coronavirus disease
2019 (COVID‐19)(severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2]) …

Efficacy of mRNA-1273 and Novavax ancestral or BA. 1 spike booster vaccines against SARS-CoV-2 BA. 5 infection in nonhuman primates

NK Routhu, SD Stampfer, L Lai, A Akhtar, X Tong… - Science …, 2023 - science.org
Omicron SARS-CoV-2 variants escape vaccine-induced neutralizing antibodies and cause
nearly all current COVID-19 cases. Here, we compared the efficacy of three booster …

BA. 2 and BA. 5 omicron differ immunologically from both BA. 1 omicron and pre-omicron variants

A Rössler, A Netzl, L Knabl, H Schäfer, SH Wilks… - Nature …, 2022 - nature.com
Several studies have shown that SARS-CoV-2 BA. 1 omicron is an immune escape variant.
Meanwhile, however, omicron BA. 2 and BA. 5 became dominant in many countries and …