[HTML][HTML] Pathogenesis and immunobiology of brucellosis: review of Brucella–Host Interactions
P de Figueiredo, TA Ficht, A Rice-Ficht… - The American journal of …, 2015 - Elsevier
This review of Brucella–host interactions and immunobiology discusses recent discoveries
as the basis for pathogenesis-informed rationales to prevent or treat brucellosis. Brucella …
as the basis for pathogenesis-informed rationales to prevent or treat brucellosis. Brucella …
The Mechanism of Facultative Intracellular Parasitism of Brucella
H Jiao, Z Zhou, B Li, Y Xiao, M Li, H Zeng… - International journal of …, 2021 - mdpi.com
Brucellosis is a highly prevalent zoonotic disease characterized by abortion and
reproductive dysfunction in pregnant animals. Although the mortality rate of Brucellosis is …
reproductive dysfunction in pregnant animals. Although the mortality rate of Brucellosis is …
Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling
Cyclic adenosine diphosphate (ADP)–ribose (cADPR) isomers are signaling molecules
produced by bacterial and plant Toll/interleukin-1 receptor (TIR) domains via nicotinamide …
produced by bacterial and plant Toll/interleukin-1 receptor (TIR) domains via nicotinamide …
Structural basis of TIR-domain-assembly formation in MAL-and MyD88-dependent TLR4 signaling
Toll-like receptor (TLR) signaling is a key innate immunity response to pathogens.
Recruitment of signaling adapters such as MAL (TIRAP) and MyD88 to the TLRs requires …
Recruitment of signaling adapters such as MAL (TIRAP) and MyD88 to the TLRs requires …
Structure and function of Toll/interleukin-1 receptor/resistance protein (TIR) domains
Abstract The Toll/interleukin-1 receptor/resistance protein (TIR) domain is a protein–protein
interaction domain consisting of 125–200 residues, widely distributed in animals, plants and …
interaction domain consisting of 125–200 residues, widely distributed in animals, plants and …
The TIR-domain containing effectors BtpA and BtpB from Brucella abortus impact NAD metabolism
JM Coronas-Serna, A Louche… - PLoS …, 2020 - journals.plos.org
Brucella species are facultative intracellular Gram-negative bacteria relevant to animal and
human health. Their ability to establish an intracellular niche and subvert host cell pathways …
human health. Their ability to establish an intracellular niche and subvert host cell pathways …
Towards the structure of the TIR-domain signalosome
Highlights•TIR domains feature in proteins associated with innate immunity in animals,
plants and bacteria.•30 structures of 16 different TIR domains from animals, plants and …
plants and bacteria.•30 structures of 16 different TIR domains from animals, plants and …
Diversity and variability of NOD-like receptors in fungi
W Dyrka, M Lamacchia, P Durrens… - Genome biology and …, 2014 - academic.oup.com
Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are intracellular
receptors that control innate immunity and other biotic interactions in animals and plants …
receptors that control innate immunity and other biotic interactions in animals and plants …
[HTML][HTML] A designed peptide-based vaccine to combat Brucella melitensis, B. suis and B. abortus: Harnessing an epitope mapping and immunoinformatics approach
H Tarrahimofrad, J Zamani, MR Hamblin… - Biomedicine & …, 2022 - Elsevier
Vaccines against Brucella abortus, B. melitensis and B. suis have been based on weakened
or killed bacteria, however there is no recombinant vaccine for disease prevention or …
or killed bacteria, however there is no recombinant vaccine for disease prevention or …
Death, TIR, and RHIM: self-assembling domains involved in innate immunity and cell-death signaling
The innate immune system consists of pattern recognition receptors (PRRs) that detect
pathogen-and endogenous danger-associated molecular patterns (PAMPs and DAMPs) …
pathogen-and endogenous danger-associated molecular patterns (PAMPs and DAMPs) …