MicroRNAs (miRNAs) are fundamental post-transcriptional modulators of several critical
cellular processes, a number of which are involved in host defense mechanisms. In …

Ten years after Fire and Melo's Nobel Prize for discovery of gene silencing by double-
stranded RNA, a remarkable progress was achieved in RNA interference (RNAi). Changes …

Cholesterol plays a significant role in stabilizing lipid or membrane rafts, which are specific
cellular membrane structures. Cholesterol is involved in numerous cellular processes …

MicroRNAs (miRNAs) are single-stranded RNAs of 17–24 nt. These molecules regulate
gene expression at the post-transcriptional level and are differentially expressed in viral …

ABSTRACT A liver-specific microRNA, miR-122, anneals to the hepatitis C virus (HCV)
genomic 5′ terminus and is essential for virus replication in cell culture. However …

Respiratory syncytial virus (RSV) infection represents an excellent paradigm of precision
medicine in modern paediatrics and several clinical trials are currently performed in the …

Replication of hepatitis C virus (HCV) RNA is influenced by a variety of microRNAs, with the
main player being the liver-specific microRNA-122 (miR-122). Binding of miR-122 to two …

A series of new conjugated compounds with a–SCH2–linkage were synthesized by
chemical methods from imidazole and coumarin derivatives. The experimental results …

RNA viruses represent the predominant cause of many clinically relevant viral diseases in
humans. Among several evolutionary advantages acquired by RNA viruses, the ability to …

Porcine reproductive and respiratory syndrome (PRRS) is one of the most important
diseases in pigs, leading to significant economic losses in swine industry worldwide. PRRS …