Mechanical activation opens a lipid-lined pore in OSCA ion channels

Y Han, Z Zhou, R Jin, F Dai, Y Ge, X Ju, X Ma, S He… - Nature, 2024 - nature.com
OSCA/TMEM63 channels are the largest known family of mechanosensitive channels,–,
playing critical roles in plant,,–and mammalian, mechanotransduction. Here we determined …

Mechanical gating of the auditory transduction channel TMC1 involves the fourth and sixth transmembrane helices

N Akyuz, KD Karavitaki, B Pan, PI Tamvakologos… - Science …, 2022 - science.org
The transmembrane (TM) channel-like 1 (TMC1) and TMC2 proteins play a central role in
auditory transduction, forming ion channels that convert sound into electrical signals …

Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels

APJ Giese, WH Weng, KS Kindt, HHV Chang… - eLife, 2025 - elifesciences.org
Calcium and integrin-binding protein 2 (CIB2) and CIB3 bind to transmembrane channel-like
1 (TMC1) and TMC2, the pore-forming subunits of the inner-ear mechano-electrical …

[图书][B] In Silico Studies of Mechanotransduction and Cell Adhesion Proteins

SP Walujkar - 2021 - search.proquest.com
Mechanical stimuli from sound and head movements are converted to electrical signal sent
to the brain by specialized cells called hair cells inside the inner ear. Hair cells are …

[引用][C] WEST AFRICAN CENTER FOR CELL BIOLOGY OF INFECTIOUS PATHOGENS DEPARTMENT OF BIOCHEMISTRY CELL AND MOLECULAR BIOLOGY …

SM ADADEY - 2020