The role of IL-6 in skin fibrosis and cutaneous wound healing

BZ Johnson, AW Stevenson, CM Prêle, MW Fear… - Biomedicines, 2020 - mdpi.com
The timely resolution of wound healing is critical for restoring the skin as a protective barrier.
The switch from a proinflammatory to a reparative microenvironment must be tightly …

Scars

MG Jeschke, FM Wood, E Middelkoop… - Nature Reviews …, 2023 - nature.com
Wound healing occurs as a response to disruption of the epidermis and dermis. It is an
intricate and well-orchestrated response with the goal to restore skin integrity and function …

Update on management of keloid and hypertrophic scars: a systemic review

ML Elsaie - Journal of cosmetic dermatology, 2021 - Wiley Online Library
Numerous therapeutic strategies have been described for prevention and reduction of
hypertrophic scars and keloids, but none of the treatments is effective in all patients. No …

Keloid treatments: an evidence-based systematic review of recent advances

LA Walsh, E Wu, D Pontes, KR Kwan, S Poondru… - Systematic reviews, 2023 - Springer
Background Keloids are pathologic scars that pose a significant functional and cosmetic
burden. They are challenging to treat, despite the multitude of treatment modalities currently …

Triamcinolone acetonide intralesional injection for the treatment of keloid scars: patient selection and perspectives

M Morelli Coppola, R Salzillo, F Segreto… - Clinical, cosmetic and …, 2018 - Taylor & Francis
Keloids are pathological scars presenting as nodular lesions that extend beyond the area of
injury. They do not spontaneously regress, often continuing to grow over time. The abnormal …

Keloids: current and emerging therapies

N Ojeh, A Bharatha, U Gaur… - Scars, burns & …, 2020 - journals.sagepub.com
Keloids are pathological scars that grow over time and extend beyond the initial site of injury
after impaired wound healing. These scars frequently recur and rarely regress. They are …

Current advances in hypertrophic scar and keloid management

N Barone, T Safran, J Vorstenbosch… - Seminars in plastic …, 2021 - thieme-connect.com
Hypertrophic scars and keloids are caused by excessive tissue response to dermal injury
due to local fibroblast proliferation and collagen overproduction. This response occurs …

A review of current keloid management: mainstay monotherapies and emerging approaches

EE Limmer, DA Glass - Dermatology and therapy, 2020 - Springer
Commonly affecting those with skin of color, keloids are an aberrant wound response that
leads to wound tissue expanding above and beyond the original cutaneous injury. Keloids …

Keloid disorder: genetic basis, gene expression profiles, and immunological modulation of the fibrotic processes in the skin

AJ Cohen, N Nikbakht, J Uitto - Cold Spring Harbor …, 2023 - cshperspectives.cshlp.org
Keloid disorder, a group of fibroproliferative skin disorders, is clinically comprised of keloids,
hypertrophic scars, keloidalis nuchae, and acne keloidalis. The prototype of these disorders …

Comparative efficacy and safety of common therapies in keloids and hypertrophic scars: a systematic review and meta-analysis

Y Bao, S Xu, Z Pan, J Deng, X Li, F Pan, X Li - Aesthetic plastic surgery, 2020 - Springer
Objectives At present, there are many therapies for treating keloids and hypertrophic scars,
but there is still a lack of treatments that are relatively balanced in efficacy and safety. The …