Antimicrobial peptides: Application informed by evolution

BP Lazzaro, M Zasloff, J Rolff - Science, 2020 - science.org
BACKGROUND Antimicrobial peptides (AMPs) are small proteins with potent antibacterial,
antiviral, and antifungal activity. AMPs are ubiquitous among multicellular eukaryotes, with …

A lasting symbiosis: how the Hawaiian bobtail squid finds and keeps its bioluminescent bacterial partner

SV Nyholm, MJ McFall-Ngai - Nature Reviews Microbiology, 2021 - nature.com
For more than 30 years, the association between the Hawaiian bobtail squid, Euprymna
scolopes, and the bioluminescent bacterium Vibrio fischeri has been studied as a model …

A lasting symbiosis: how Vibrio fischeri finds a squid partner and persists within its natural host

KL Visick, EV Stabb, EG Ruby - Nature Reviews Microbiology, 2021 - nature.com
As our understanding of the human microbiome progresses, so does the need for natural
experimental animal models that promote a mechanistic understanding of beneficial …

Symbiotic organs shaped by distinct modes of genome evolution in cephalopods

M Belcaid, G Casaburi, SJ McAnulty… - Proceedings of the …, 2019 - National Acad Sciences
Microbes have been critical drivers of evolutionary innovation in animals. To understand the
processes that influence the origin of specialized symbiotic organs, we report the …

Role of antimicrobial peptides in controlling symbiotic bacterial populations

P Mergaert - Natural product reports, 2018 - pubs.rsc.org
Covering: up to 2018 Antimicrobial peptides (AMPs) have been known for well over three
decades as crucial mediators of the innate immune response in animals and plants, where …

Achieving a multi-strain symbiosis: strain behavior and infection dynamics

C Bongrand, EG Ruby - The ISME journal, 2019 - academic.oup.com
Strain diversity, while now recognized as a key driver underlying partner dynamics in
symbioses, is usually difficult to experimentally manipulate and image in hosts with complex …

Bacteria primed by antimicrobial peptides develop tolerance and persist

A Rodríguez-Rojas, DY Baeder, P Johnston… - PLoS …, 2021 - journals.plos.org
Antimicrobial peptides (AMPs) are key components of innate immune defenses. Because of
the antibiotic crisis, AMPs have also come into focus as new drugs. Here, we explore …

Host-Microbe Interactions in the Chemosynthetic Riftia pachyptila Symbiosis

T Hinzke, M Kleiner, C Breusing, H Felbeck, R Häsler… - Mbio, 2019 - Am Soc Microbiol
The deep-sea tubeworm Riftia pachyptila lacks a digestive system but completely relies on
bacterial endosymbionts for nutrition. Although the symbiont has been studied in detail on …

Immune-mediated competition benefits protective microbes over pathogens in a novel host species

SA Ford, GC Drew, KC King - Heredity, 2022 - nature.com
Microbes that protect against infection inhabit hosts across the tree of life. It is unclear
whether and how the host immune system may affect the formation of new protective …

Experimental Infection of the Biomphalaria glabrata Vector Snail by Schistosoma mansoni Parasites Drives Snail Microbiota Dysbiosis

A Portet, E Toulza, A Lokmer, C Huot, D Duval… - Microorganisms, 2021 - mdpi.com
Host-parasite interaction can result in a strong alteration of the host-associated microbiota.
This dysbiosis can affect the fitness of the host; can modify pathogen interaction and the …