[HTML][HTML] Role of microbiota-derived short-chain fatty acids in cancer development and prevention
R Mirzaei, A Afaghi, S Babakhani, MR Sohrabi… - Biomedicine & …, 2021 - Elsevier
Following cancer, cells in a particular tissue can no longer respond to the factors involved in
controlling cell survival, differentiation, proliferation, and death. In recent years, it has been …
controlling cell survival, differentiation, proliferation, and death. In recent years, it has been …
Targeting cell cycle regulation in cancer therapy
S Diaz-Moralli, M Tarrado-Castellarnau… - Pharmacology & …, 2013 - Elsevier
Cell proliferation is an essential mechanism for growth, development and regeneration of
eukaryotic organisms; however, it is also the cause of one of the most devastating diseases …
eukaryotic organisms; however, it is also the cause of one of the most devastating diseases …
Multiple roles of the cell cycle inhibitor p21CDKN1A in the DNA damage response
Among cell cycle regulatory proteins that are activated following DNA damage, the cyclin-
dependent kinase inhibitor p21CDKN1A plays essential roles in the DNA damage response …
dependent kinase inhibitor p21CDKN1A plays essential roles in the DNA damage response …
Biology of the cell cycle inhibitor p21CDKN1A: molecular mechanisms and relevance in chemical toxicology
I Dutto, M Tillhon, O Cazzalini, LA Stivala… - Archives of toxicology, 2015 - Springer
The cell cycle inhibitor p21 CDKN1A is a protein playing multiple roles not only in the DNA
damage response, but also in many cellular processes during unperturbed cell growth. The …
damage response, but also in many cellular processes during unperturbed cell growth. The …
Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1
BH Huang, M Laban, CHW Leung, L Lee… - Cell Death & …, 2005 - nature.com
Abstract Histone deacetylases (HDACs) 1 and 2 share a high degree of homology and
coexist within the same protein complexes. Despite their close association, each possesses …
coexist within the same protein complexes. Despite their close association, each possesses …
The butyrate story: old wine in new bottles?
W Scheppach, F Weiler - Current Opinion in Clinical Nutrition & …, 2004 - journals.lww.com
In the era of molecular biology our understanding of subcellular processes that ultimately
lead to inflammatory bowel disease or colorectal cancer has widened considerably. The …
lead to inflammatory bowel disease or colorectal cancer has widened considerably. The …
Functional interplay between histone demethylase and deacetylase enzymes
Histone deacetylase (HDAC) inhibitors are a promising class of anticancer agents for the
treatment of solid and hematological malignancies. The precise mechanism by which HDAC …
treatment of solid and hematological malignancies. The precise mechanism by which HDAC …
Role of histone deacetylases in carcinogenesis: potential role in cholangiocarcinoma
Cholangiocarcinoma (CCA) is a highly invasive and metastatic form of carcinoma with bleak
prognosis due to limited therapies, frequent relapse, and chemotherapy resistance. There is …
prognosis due to limited therapies, frequent relapse, and chemotherapy resistance. There is …
Gut metabolites and breast cancer: the continuum of dysbiosis, breast cancer risk, and potential breast cancer therapy
The complex association between the gut microbiome and cancer development has been
an emerging field of study in recent years. The gut microbiome plays a crucial role in the …
an emerging field of study in recent years. The gut microbiome plays a crucial role in the …
Emerging role of histone deacetylase inhibitors as anti-breast-cancer agents
Highlights•Breast cancer is the most frequently diagnosed cancer in women.•Aberrant
expression of HATs and HDACs has been reported in breast cancer.•Epigenetic therapy is …
expression of HATs and HDACs has been reported in breast cancer.•Epigenetic therapy is …