Region and species dependent mechanical properties of adolescent and young adult brain tissue

DB MacManus, B Pierrat, JG Murphy, MD Gilchrist - Scientific reports, 2017 - nature.com
Traumatic brain injuries, the leading cause of death and disability in children and young
adults, are the result of a rapid acceleration or impact of the head. In recent years, a global …

Integrating human and nonhuman primate data to estimate human tolerances for traumatic brain injury

T Wu, F Sato, J Antona-Makoshi… - Journal of …, 2022 - asmedigitalcollection.asme.org
Traumatic brain injury (TBI) contributes to a significant portion of the injuries resulting from
motor vehicle crashes, falls, and sports collisions. The development of advanced …

A review on injury mechanism of intracerebral hemorrhage in vehicle accidents

F Li, H Li, Z Xiao, R Lu, Z Zhang… - Current …, 2017 - ingentaconnect.com
Background: Intracerebral hemorrhage is one of the most common injuries in vehicle
accidents. The aim of this paper is to survey the injury mechanism of intracerebral …

Investigation of cross-species scaling methods for traumatic brain injury using finite element analysis

T Wu, J Antona-Makoshi, A Alshareef… - Journal of …, 2020 - liebertpub.com
Scaling methods are used to relate animal exposure data to humans by determining
equivalent biomechanical impact conditions that result in similar tissue-level mechanics for …

Protection of cortex by overlying meninges tissue during dynamic indentation of the adolescent brain

DB MacManus, B Pierrat, JG Murphy, MD Gilchrist - Acta biomaterialia, 2017 - Elsevier
Traumatic brain injury (TBI) has become a recent focus of biomedical research with a
growing international effort targeting material characterization of brain tissue and …

A viscoelastic analysis of the P56 mouse brain under large-deformation dynamic indentation

DB MacManus, B Pierrat, JG Murphy, MD Gilchrist - Acta Biomaterialia, 2017 - Elsevier
The brain is a complex organ made up of many different functional and structural regions
consisting of different types of cells such as neurons and glia, as well as complex anatomical …

A mechanistic end-to-end concussion model that translates head kinematics to neurologic injury

LJ Ng, V Volman, MM Gibbons, P Phohomsiri… - Frontiers in …, 2017 - frontiersin.org
Past concussion studies have focused on understanding the injury processes occurring on
discrete length scales (eg, tissue-level stresses and strains, cell-level stresses and strains …

Validation of Local Brain Kinematics of a Novel Rat Brain Finite Element Model under Rotational Acceleration-Clarification of Diffuse Axonal Injury Mechanisms

AM Jacobo, D Johan, R Marten, S Ejima… - International Journal of …, 2014 - jstage.jst.go.jp
Relative brain-skull displacement under head rotational acceleration in rats was evaluated
experimentally. For this, a thin pin was entered the cortex and rigidly attached to the skull …

Development of a subhuman primate brain finite element model to investigate brain injury thresholds induced by head rotation

T Arora - 2018 - search.proquest.com
The brain is the most critical organ of the human body as it controls motor function,
information flow and body actions. Thus, the brain needs to be protected from trauma …

[PDF][PDF] Correlation of global head and brain tissue injury criteria to experimental concussion derived from monkey head trauma experiments

J Antona-Makoshi, J Davidsson, S Ejima, K Ono… - IRCOBI …, 2013 - ircobi.org
A series of 24 frontal head traumatic impacts on macaques carried out in the past were
simulated with a validated finite element model of the specimens. From these simulations …