The concept of a matricellular protein was first proposed by Paul Bornstein in the mid-1990s
to account for the non-lethal phenotypes of mice with inactivated genes encoding …

The term matricellular proteins describes a family of structurally unrelated extracellular
macromolecules that, unlike structural matrix proteins, do not play a primary role in tissue …

Spermatogenesis is the process by which a single spermatogonium develops into 256
spermatozoa, one of which will fertilize the ovum. Since the 1950s when the stages of the …

The LDL receptor-related protein (originally called LRP, but now referred to as LRP1) is a
large endocytic receptor that is widely expressed in several tissues. LRP1 is a member of …

The extracellular matrix molecule tenascin-C is highly expressed during embryonic
development, tissue repair and in pathological situations such as chronic inflammation and …

The determination of animal form depends on the coordination of events that lead to the
morphological patterning of cells. This epigenetic view of development suggests that …

Tenascin-C is a large, multimodular, extracellular matrix glycoprotein that exhibits a very
restricted pattern of expression but an enormously diverse range of functions. Here, we …

In this review, we discuss the structure and function of the extracellular matrix protein family
of tenascins with emphasis on their involvement in human pathologies. The article is divided …

Tenascin-C is an extracellular matrix glycoprotein that is specifically and transiently
expressed upon tissue injury. Upon tissue damage, tenascin-C plays a multitude of different …

Clustering of integrins into focal adhesions and focal complexes is regulated by the actin
cytoskeleton. In turn, actin dynamics are governed by Rho family GTPases. Integrin …