Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …

Engineered human cardiac tissues facilitate progress in regenerative medicine, disease
modelling and drug development. In this Perspective, we reflect on the most notable …

Three-dimensional (3D) cell culture is often mentioned in the context of regenerative
medicine, for example, for the replacement of ischemic myocardium with tissue-engineered …

Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating
research to improve diagnostics, and to discover and test novel preventive and curative …

Abstract Development of new drugs is of high interest for the field of cardiac and
cardiovascular diseases, which are a dominant cause of death worldwide. Before being …

In this brief review, we discuss the recent advancements in using poly (ethylene glycol)
diacrylate (PEGDA) hydrogels for tissue engineering applications. PEGDA hydrogels are …

Advances in our understanding of cardiovascular development have provided a roadmap for
the directed differentiation of human pluripotent stem cells (hPSCs) to the major cell types …

The convergence of tissue engineering and patient-specific stem cell biology has enabled
the engineering of in vitro tissue models that allow the study of patient-tailored treatment …

The ability of human pluripotent stem cells to form all cells of the body has provided many
opportunities to study disease and produce cells that can be used for therapy in …

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are commercially
available, and cardiac differentiation established routine. Systematic evaluation of several …