Monoclonal antibodies (mAbs) are a fast-growing class of biopharmaceuticals. They are
widely used in the identification and detection of cell makers, serum analytes, and …

Recent development of methods to discover and engineer therapeutic T‐cell receptors
(TCRs) or antibody mimics of TCRs, and to understand their immunology and …

The use of antibodies in the treatment of lung diseases is of increasing interest especially as
the search for COVID-19 therapies has unfolded. Historically, the use of antibody therapy …

The formation of inclusion bodies (IBs) during expression of recombinant therapeutic
proteins using E. coli is a significant hurdle in producing high-quality, safe, and efficacious …

Characterizing changes in the higher order structure (HOS) of monoclonal antibodies upon
stressed conditions is critical to gaining a better understanding of the product and process …

The higher order structure (HOS) of monoclonal antibodies (mAbs) is an important quality
attribute with strong contribution to clinically relevant biological functions and drug safety …

This review highlights recent advancements in using high resolution nuclear magnetic
resonance (NMR) spectroscopy as a characterization tool to expedite biologics formulation …

Recombinant expression of proteins, propelled by therapeutic antibodies, has evolved into a
multibillion dollar industry. Essential here is the quality control assessment of critical …

Biotherapeutic's higher order structure (HOS) is a critical determinant of its functional
properties and conformational relevance. Here, we evaluated two covalent labeling …

Antibody drug conjugates (ADCs) represent one of the fastest growing classes of cancer
therapeutics. Drug incorporation through site-specific conjugation in ADCs leads to uniform …