Environmental toxicants and autism spectrum disorders: a systematic review

DA Rossignol, SJ Genuis, RE Frye - Translational psychiatry, 2014 - nature.com
Although the involvement of genetic abnormalities in autism spectrum disorders (ASD) is
well-accepted, recent studies point to an equal contribution by environmental factors …

Neurotoxicity of polychlorinated biphenyls and related organohalogens

IN Pessah, PJ Lein, RF Seegal, SK Sagiv - Acta neuropathologica, 2019 - Springer
Halogenated organic compounds are pervasive in natural and built environments. Despite
restrictions on the production of many of these compounds in most parts of the world through …

Cytokine dysregulation in autism spectrum disorders (ASD): possible role of the environment

PE Goines, P Ashwood - Neurotoxicology and teratology, 2013 - Elsevier
Autism spectrum disorders (ASD) are neurodevelopmental diseases that affect an alarming
number of individuals. The etiological basis of ASD is unclear, and evidence suggests it …

Activity-dependent regulation of inhibitory synapse development by Npas4

Y Lin, BL Bloodgood, JL Hauser, AD Lapan, AC Koon… - Nature, 2008 - nature.com
Neuronal activity regulates the development and maturation of excitatory and inhibitory
synapses in the mammalian brain. Several recent studies have identified signalling …

Developmental sensory experience balances cortical excitation and inhibition

AL Dorrn, K Yuan, AJ Barker, CE Schreiner… - Nature, 2010 - nature.com
Early in life, neural circuits are highly susceptible to outside influences. The organization of
the primary auditory cortex (A1) in particular is governed by acoustic experience during the …

Evidence implicating non-dioxin-like congeners as the key mediators of polychlorinated biphenyl (PCB) developmental neurotoxicity

C Klocke, PJ Lein - International journal of molecular sciences, 2020 - mdpi.com
Despite being banned from production for decades, polychlorinated biphenyls (PCBs)
continue to pose a significant risk to human health. This is due to not only the continued …

Polychlorinated biphenyls: New evidence from the last decade

O Faroon, P Ruiz - Toxicology and industrial health, 2016 - journals.sagepub.com
Millions of pounds of polychlorinated biphenyl (PCB) compounds have been produced in
multiple countries for industrial applications over the last several decades. PCB exposure …

Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca2+/Calmodulin-dependent protein kinase II

L Ciani, KA Boyle, E Dickins… - Proceedings of the …, 2011 - National Acad Sciences
The balance between excitatory and inhibitory synapses is crucial for normal brain function.
Wnt proteins stimulate synapse formation by increasing synaptic assembly. However, it is …

Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity

IN Pessah, G Cherednichenko, PJ Lein - Pharmacology & therapeutics, 2010 - Elsevier
Chronic low-level polychlorinated biphenyl (PCB) exposures remain a significant public
health concern since results from epidemiological studies indicate that PCB burden is …

Tipping the balance of autism risk: potential mechanisms linking pesticides and autism

JF Shelton, I Hertz-Picciotto… - Environmental health …, 2012 - ehp.niehs.nih.gov
Background: Autism spectrum disorders (ASDs) have been increasing in many parts of the
world and a portion of cases are attributable to environmental exposures. Conclusive …