Effects of reactive oxygen and nitrogen species on TrkA expression and signalling: implications for proNGF in aging and Alzheimer's disease

E Kropf, M Fahnestock - Cells, 2021 - mdpi.com
Nerve growth factor (NGF) and its precursor form, proNGF, are critical for neuronal survival
and cognitive function. In the brain, proNGF is the only detectable form of NGF …

Alpha-synuclein toxicity on protein quality control, mitochondria and endoplasmic reticulum

TQ Melo, SJ Copray, MFR Ferrari - Neurochemical research, 2018 - Springer
Parkinson's disease (PD) is characterized by the presence of insoluble protein clusters
containing α-synuclein. Impairment of mitochondria, endoplasmic reticulum, autophagy and …

A new zebrafish model to measure neuronal α-synuclein clearance in vivo

A Lopez, A Gorb, N Palha, A Fleming, DC Rubinsztein - Genes, 2022 - mdpi.com
The accumulation and aggregation of α-synuclein (α-SYN) is a common characteristic of
synucleinopathies, such as Parkinson's Disease (PD), Dementia with Lewy Bodies (DLB) or …

Impairment of mitochondria dynamics by human A53T α-synuclein and rescue by NAP (davunetide) in a cell model for Parkinson's disease

TQ Melo, KC van Zomeren, MFR Ferrari… - Experimental brain …, 2017 - Springer
The formation of oligomers and aggregates of overexpressed or mutant α-synuclein play a
role in the degeneration of dopaminergic neurons in Parkinson's disease by causing …

Effects of mild running on substantia nigra during early neurodegeneration

MF Almeida, CM Silva, RS Chaves… - Journal of sports …, 2018 - Taylor & Francis
Moderate physical exercise acts at molecular and behavioural levels, such as interfering in
neuroplasticity, cell death, neurogenesis, cognition and motor functions. Therefore, the aim …

Minocycline diminishes the rotenone induced neurotoxicity and glial activation via suppression of apoptosis, nitrite levels and oxidative stress

DK Verma, DK Singh, S Gupta, P Gupta, A Singh… - Neurotoxicology, 2018 - Elsevier
The study was conducted to evaluate the effect of minocycline against pesticide rotenone
induced adverse effects in different rat brain regions. Assessment of oxidative stress, nitrite …

Metabolic enhancer piracetam attenuates rotenone induced oxidative stress: a study in different rat brain regions

D Verma, N Joshi, K Raju, M Wahajuddin… - Acta Neurobiologiae …, 2015 - ane.pl
Piracetam is clinically being used nootropic drug but the details of its neuroprotective
mechanism are not well studied. The present study was conducted to assess the effects of …

[HTML][HTML] BDNF trafficking and signaling impairment during early neurodegeneration is prevented by moderate physical activity

MF Almeida, RS Chaves, CM Silva, JCS Chaves… - IBRO reports, 2016 - Elsevier
Physical exercise can attenuate the effects of aging on the central nervous system by
increasing the expression of neurotrophins such as brain-derived neurotrophic factor …

[HTML][HTML] 中国汉族人群SNPH基因多态性与精神分裂症的关联研究

巫珺, 陆佳晶, 黄欣欣, 黄茹燕, 吕钦谕… - 复旦学报(医学版), 2022 - jms.fudan.edu.cn
目的探讨伸展蛋白(syntaphilin, SNPH) 基因与中国汉族人群精神分裂症(schizophrenia, SZ)
之间的关联性. 方法采用TaqMan 探针基因分型技术对389 例SZ 患者(病例组) 和433 …

[PDF][PDF] A New Zebrafish Model to Measure Neuronal α-Synuclein Clearance In Vivo. Genes 2022, 13, 868

A Lopez, A Gorb, N Palha, A Fleming, DC Rubinsztein - 2022 - academia.edu
The accumulation and aggregation of α-synuclein (α-SYN) is a common characteristic of
synucleinopathies, such as Parkinson's Disease (PD), Dementia with Lewy Bodies (DLB) or …