A guide to membraneless organelles and their various roles in gene regulation

T Hirose, K Ninomiya, S Nakagawa… - … Reviews Molecular Cell …, 2023 - nature.com
Membraneless organelles (MLOs) are detected in cells as dots of mesoscopic size. By
undergoing phase separation into a liquid-like or gel-like phase, MLOs contribute to …

Modulating biomolecular condensates: a novel approach to drug discovery

DM Mitrea, M Mittasch, BF Gomes, IA Klein… - Nature Reviews Drug …, 2022 - nature.com
In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …

A framework for understanding the functions of biomolecular condensates across scales

AS Lyon, WB Peeples, MK Rosen - Nature Reviews Molecular Cell …, 2021 - nature.com
Biomolecular condensates are found throughout eukaryotic cells, including in the nucleus, in
the cytoplasm and on membranes. They are also implicated in a wide range of cellular …

[HTML][HTML] Phase separation and neurodegenerative diseases: a disturbance in the force

A Zbinden, M Pérez-Berlanga, P De Rossi… - Developmental cell, 2020 - cell.com
Protein aggregation is the main hallmark of neurodegenerative diseases. Many proteins
found in pathological inclusions are known to undergo liquid-liquid phase separation, a …

Regulation of biomolecular condensates by interfacial protein clusters

AW Folkmann, A Putnam, CF Lee, G Seydoux - Science, 2021 - science.org
Biomolecular condensates are cellular compartments that can form by phase separation in
the absence of limiting membranes. Studying the P granules of Caenorhabditis elegans, we …

Biomolecular phase separation: from molecular driving forces to macroscopic properties

GL Dignon, RB Best, J Mittal - Annual review of physical …, 2020 - annualreviews.org
Biological phase separation is known to be important for cellular organization, which has
recently been extended to a new class of biomolecules that form liquid-like droplets …

RNA contributions to the form and function of biomolecular condensates

C Roden, AS Gladfelter - Nature Reviews Molecular Cell Biology, 2021 - nature.com
Biomolecular condensation partitions cellular contents and has important roles in stress
responses, maintaining homeostasis, development and disease. Many nuclear and …

Liquid phase condensation in cell physiology and disease

Y Shin, CP Brangwynne - Science, 2017 - science.org
BACKGROUND Living cells contain distinct subcompartments to facilitate spatiotemporal
regulation of biological reactions. In addition to canonical membrane-bound organelles such …

Biomolecular condensates: organizers of cellular biochemistry

SF Banani, HO Lee, AA Hyman… - Nature reviews Molecular …, 2017 - nature.com
Biomolecular condensates are micron-scale compartments in eukaryotic cells that lack
surrounding membranes but function to concentrate proteins and nucleic acids. These …

Coexisting liquid phases underlie nucleolar subcompartments

M Feric, N Vaidya, TS Harmon, DM Mitrea, L Zhu… - Cell, 2016 - cell.com
The nucleolus and other ribonucleoprotein (RNP) bodies are membrane-less organelles
that appear to assemble through phase separation of their molecular components. However …