Galectin-9–ligand axis: an emerging therapeutic target for multiple myeloma

RK Shil, NBB Mohammed, CJ Dimitroff - Frontiers in Immunology, 2024 - frontiersin.org
Galectin-9 (Gal-9) is a tandem-repeat galectin with diverse roles in immune homeostasis,
inflammation, malignancy, and autoimmune diseases. In cancer, Gal-9 displays variable …

Cancer fitness genes: emerging therapeutic targets for metastasis

M Shen, Y Kang - Trends in Cancer, 2023 - cell.com
Development of cancer therapeutics has traditionally focused on targeting driver oncogenes.
Such an approach is limited by toxicity to normal tissues and treatment resistance. A class of …

Pattern analysis of serum galectins-1,-3, and-9 in breast cancer

A Funkhouser, H Shuster, JC Martin, WJ Edenfield… - Cancers, 2023 - mdpi.com
Simple Summary This study aims to understand the role of galectins by breast cancer
subtype and their change in response to cancer treatment. Galectins are proteins involved in …

Enhanced expression of galectin‐9 in triple negative breast cancer cells following radiotherapy: Implications for targeted therapy

C Lerévérend, N Kotaich, L Cartier… - … Journal of Cancer, 2025 - Wiley Online Library
Optimizations are expected in the development of immunotherapy for the treatment of Triple‐
negative breast cancer (TNBC). We studied the expression of galectin‐9 (Gal‐9) after …

ANXA9 facilitates S100A4 and promotes breast cancer progression through modulating STAT3 pathway

X Zhou, J Zhao, T Yan, D Ye, Y Wang, B Zhou… - Cell Death & …, 2024 - nature.com
Breast cancer has the highest global incidence and mortality rates among all cancer types.
Abnormal expression of the Annexin family has been observed in different malignant tumors …

Galectin-9 in cancer therapy: from immune checkpoint ligand to promising therapeutic target

M Zhang, C Liu, Y Li, H Li, W Zhang, J Liu… - Frontiers in cell and …, 2024 - frontiersin.org
Galectin-9 (Gal-9) is a vital member of the galectin family, functioning as a multi-subtype
galactose lectin with diverse biological roles. Recent research has revealed that Gal-9's …

[HTML][HTML] Bulky glycocalyx shields cancer cells from invasion-associated stresses

N Piplani, T Roy, N Saxena, S Sen - Translational Oncology, 2024 - Elsevier
The glycocalyx—that forms a protective barrier around cells—has been implicated in cancer
cell proliferation, survival, and metastasis. However, its role in maintaining the integrity of …

A microphysiological system reveals neutrophil contact-dependent attenuation of pancreatic tumor progression by CXCR2 inhibition-based immunotherapy

S Shao, NA Delk, CN Jones - Scientific Reports, 2024 - nature.com
Cancer cells recruit neutrophils from the bloodstream into the tumor tissue, where these
immune cells promote the progression of numerous solid tumors. Studies in mice suggest …

The variations' in genes encoding TIM-3 and its ligand, galectin-9, influence on ccRCC risk and prognosis

A Andrzejczak, K Tupikowski, A Tomkiewicz… - International Journal of …, 2023 - mdpi.com
Renal cell cancer is the most common type of kidney cancer in adults, and clear cell renal
cell carcinoma (ccRCC) is the most diagnosed type. T cell immunoglobulin and mucin …

Pan-inhibition of the three H2S synthesizing enzymes restrains tumor progression and immunosuppression in breast cancer

A Dawoud, RA Youness, H Nafea, T Manie… - Cancer Cell …, 2024 - Springer
Abstract Background Hydrogen sulfide (H2S) is a significant endogenous mediator that has
been implicated in the progression of various forms of cancer including breast cancer (BC) …