Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are uniquely
required to balance the formation of new blood vessels with the maintenance and …

Vascular endothelial growth factors (VEGFs) are best known for their involvement in
orchestrating the development and maintenance of the blood and lymphatic vascular …

Macrophages, the most plastic cells of the haematopoietic system, are found in all tissues
and show great functional diversity. They have roles in development, homeostasis, tissue …

The vast blood-vessel network of the circulatory system is crucial for maintaining bodily
homeostasis, delivering essential molecules and blood cells, and removing waste products …

The generation of new lymphatic vessels through lymphangiogenesis and the remodelling
of existing lymphatics are thought to be important steps in cancer metastasis. The past …

The blood-brain barrier (BBB), constituted by an extensive network of endothelial cells (ECs)
together with neurons and glial cells, including microglia, forms the neurovascular unit …

Dysfunctional endothelium contributes to more diseases than any other tissue in the body.
Small interfering RNAs (siRNAs) can help in the study and treatment of endothelial cells in …

Pharmacological inhibition of VEGF-A has proven to be effective in inhibiting angiogenesis
and vascular leak associated with cancers and various eye diseases. However, little …

Tie-1 and Tie-2 tyrosine kinase receptors are expressed specifically on vascular endothelial
cells and on a certain subtype of macrophages implicated in angiogenesis, thus, they have …

Blood vessels form a closed circulatory system, whereas lymphatic vessels form a one-way
conduit for tissue fluid and leukocytes. In most vertebrates, the main function of lymphatic …