Polycystic ovary syndrome (PCOS) is a very common endocrine disorder characterized by
chronic anovulation, clinical and/or biochemical hyperandrogenism, and/or polycystic …

Classically, aldosterone is synthesised in the adrenal zona glomerulosa and binds to
specific mineralocorticoid receptors located in the cytosol of target epithelial cells …

Context: The human adrenal zona fasciculata (ZF) and zona reticularis (ZR) are responsible
for the production of cortisol and 19-carbon steroids (often called adrenal androgens) …

The adrenal cortex is a critical steroidogenic endocrine tissue, generated at least in part from
the coelomic epithelium of the urogenital ridge. Neither the intercellular signals that regulate …

The human adrenal cortex secretes mineralocorticoids, glucocorticoids and adrenal
androgens. These steroids are produced from unique cell types located within the three …

Up to 15% of patients with essential hypertension have inappropriate regulation of
aldosterone; although only a minority have distinct adrenal tumors, recent evidence shows …

The pituitary adrenocorticotropic hormone (ACTH) plays a pivotal role in homeostasis and
stress response and is thus the major component of the hypothalamo–pituitary–adrenal axis …

The standard model of adrenocortical zonation holds that the three main zones,
glomerulosa, fasciculata, and reticularis each have a distinct function, producing …

The adrenal gland is of critical importance for a plethora of biological processes. We
performed the first systematic analysis of adrenal gland growth using unbiased stereological …

The purpose of this article is to review fundamentals in adrenal gland histophysiology. Key
findings regarding the important signaling pathways involved in the regulation of …