The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an
important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage …

Osteoarthritis (OA) is the most common musculoskeletal disease, affecting millions of
individuals worldwide. New treatment approaches require an understanding of the …

Osteoarthritis is a complex disease involving the mechanical breakdown of articular
cartilage in the presence of altered joint mechanics and chondrocyte death, but the …

Abstract Proteoglycan 4 (PRG4/lubricin) is secreted by cells that reside in articular cartilage
and line the synovial joint. Lubricin may play a role in modulating inflammatory responses …

Abstract Background Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted
by synovial fibroblasts and superficial zone chondrocytes. PRG4 has a homeostatic …

Importance Lubricin may be an important barrier to the development of corneal and
conjunctival epitheliopathies that may occur in dry eye disease and contact lens wear …

The superficial zone of articular cartilage contributes to smooth joint motion through the
production of proteoglycan 4 (PRG4), also known as lubricin. Recent studies indicate novel …

Objective To evaluate the binding of recombinant human proteoglycan 4 (rhPRG4) to CD44
receptor and its consequences on cytokine‐induced synoviocyte proliferation. Methods The …

Patients with osteoarthritis (OA) primarily seek treatment due to pain and disability, yet the
primary endpoints for rodent OA models tend to be histological measures of joint destruction …