Migraine is a complex neurovascular disorder that is characterized by severe behavioral,
sensory, visual, and/or auditory symptoms. It has been labeled as one of the ten most …

Simple Summary Thyroid tumors represent the most common neoplastic pathology of the
endocrine system. Mutations occurring in oncogenes and tumor suppressor genes are …

Introduction The main objective was to carry out a global DNA methylation analysis in a
population with gender incongruence before gender-affirming hormone treatment (GAHT), in …

Integration of human papillomavirus (HPV) viral DNA into the human genome has been
postulated as an important etiological event during cervical carcinogenesis. Several recent …

Background Epigenetic alternation is a common contributing factor to neoplastic
transformation. Although previous studies have reported a cluster of aberrant promoter …

Resistance to endocrine therapy in breast cancer is common. With the aim of discovering
new molecular targets for breast cancer therapy, we have recently identified LMTK3 as a …

Background Gene silencing by aberrant DNA methylation of promoter regions remains the
most dominant phenomenon occurring during tumorigenesis. Improving the early diagnosis …

Abstract Background Ultra-conserved regions (UCRs) are segments of the genome (≥ 200
bp) that exhibit 100% DNA sequence conservation between human, mouse and rat …

Long-term persistent viral infections cause substantial morbidity and associated economic
losses in human and veterinary contexts. Yet, the mechanisms associated with …

Novel molecular-targeted treatments show great prospects for radioiodine-refractory and
surgically inoperable thyroid carcinomas. While aberrations in protein-coding genes are a …