Recent insights about pyrrolidine core skeletons in pharmacology

S Poyraz, HA Döndaş, NY Döndaş… - Frontiers in …, 2023 - frontiersin.org
To overcome numerous health disorders, heterocyclic structures of synthetic or natural origin
are utilized, and notably, the emergence of various side effects of existing drugs used for …

Progress on the Chemical Constituents Derived from Glucosinolates in Maca (Lepidium meyenii)

YJ Huang, XR Peng, MH Qiu - Natural products and bioprospecting, 2018 - Springer
Abstract Maca (Lepidium meyenii Walp.), a famous food supplement, has drawn an
unprecedented international interest over the last two decades. It was assumed that …

Synthesis and antimicrobial activity of thiohydantoins obtained from L-amino acids

PGC de Carvalho, JM Ribeiro… - Letters in Drug …, 2020 - ingentaconnect.com
Background: Thiohydantoins are an important class of heterocyclic compounds in drug
discovery since they are related to a wide range of biological properties including …

Design, synthesis, biological evaluation and docking analysis of pyrrolidine-benzenesulfonamides as carbonic anhydrase or acetylcholinesterase inhibitors and …

S Poyraz, HA Döndaş, C Yamali… - Journal of …, 2024 - Taylor & Francis
The synthesis and biological assessment of novel multi-functionalized pyrrolidine-containing
benzenesulfonamides were reported along with their antimicrobial, antifungal, CAs …

[HTML][HTML] Lepidium peruvianum as a Source of Compounds with Anticancer and Cosmetic Applications

D Kasprzak, K Gaweł-Bęben, W Kukula-Koch… - International Journal of …, 2024 - mdpi.com
Lepidium peruvianum—an edible herbaceous biennial plant distributed in the Andes—has
been used for centuries as food and as a natural medicine in treating hormonal disorders, as …

N-Benzoylthiourea-pyrrolidine carboxylic acid derivatives bearing an imidazole moiety: Synthesis, characterization, crystal structure, in vitro ChEs inhibition, and …

S Poyraz, HA Döndaş, JM Sansano, S Belveren… - Journal of Molecular …, 2023 - Elsevier
A series of novel N-benzoylthiourea-pyrrolidine carboxylic acid derivatives bearing an
imidazole moiety has been prepared and their various biological activities are evaluated …

Iron‐catalyzed construction of cyanomethylated thiohydantoins by cross‐dehydrogenative C(sp3)‐C(sp3) coupling

MI Morja, RB Moradiya, BS Makwana… - Journal of …, 2023 - Wiley Online Library
The efficient and novel approach for synthesizing cyanomethylated thiohydantoin from
readily obtainable acetonitrile and 1, 3‐dibenzyl‐2‐thiohydantoin through iron (II)‐catalyzed …

Synthesis, characterization, antioxidant properties and DFT calculation of some new pyrimidine derivatives

E Akbas, E Ergan, E Sahin, S Ekin, M Cakir… - … , Sulfur, and Silicon …, 2019 - Taylor & Francis
Abstract In this study, 5-benzoyl-4-(4-(methylthio) phenyl)-6-phenyl-1, 2, 3, 4-tetrahydro-2-
thioxo (1), oxo (2) and imino (3) pyrimidine derivatives were prepared via Multicomponent …

[PDF][PDF] ACID IONIZATION CONSTANT OF POTENTIAL BIOACTIVE FUNCTIONALIZED N BENZOYLTHIOUREA/2-THIOHYDANTOIN-PYRROLIDINE DERIVATIVES BY …

S Poyraz, H DÖNDAŞ, S Belveren… - Revue Roumaine de …, 2024 - revroum.lew.ro
The acid ionization constants (pKa) of the N-benzoylthiourea/2-thiohydantoin-pyrrolidines
were determined by the potentiometric titration method. Titrations were performed by adding …

From bioactive pyrrolidino [3, 4-c] pyrrolidines to more bioactive pyrrolidino [3, 4-b] pyrrolidines via ring-opening/ring-closing promoted by sodium methoxide

S Belveren, O Larranaga, S Poyraz, HA Dondas… - …, 2019 - thieme-connect.com
The process involving a rearrangement of pyrrolidino [3, 4-c] pyrrolidine to another
pyrrolidino [3, 4-b] pyrrolidine using sodium methoxide as base is fully studied. The effects of …