The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

Akt kinase, a member of AGC kinases, is important in many cellular functions including
proliferation, migration, cell growth and metabolism. There are three known Akt isoforms …

Colorectal cancer (CRC) at advanced stages is rarely curable, underscoring the importance
of exploring the mechanism of CRC progression and invasion. NOD-like receptor family …

The epidemic of type 2 diabetes and impaired glucose tolerance is one of the main causes
of morbidity and mortality worldwide. In both disorders, tissues such as muscle, fat and liver …

Insulin resistance is a hallmark of type 2 diabetes mellitus and is associated with a metabolic
and cardiovascular cluster of disorders (dyslipidaemia, hypertension, obesity [especially …

Abstract GLYCOGEN synthase kinase-3 (GSK3) 1 is implicated in the regulation of several
physiological processes, including the control of glycogen2 and protein3 synthesis by …

IN Western Europe and the United States approximately 1 in 12 women develop breast
cancer. A small proportion of breast cancer cases, in particular those arising at a young age …

Insulin resistance in skeletal muscle is manifested by decreased insulin‐stimulated glucose
uptake and results from impaired insulin signaling and multiple post‐receptor intracellular …

A discussion of the pathogenesis of type 2 diabetes mellitus must start with a review of
mechanisms involved in the maintenance of normal glucose homeostasis in the basal or …

Short term high fat feeding in rats results specifically in hepatic fat accumulation and
provides a model of non-alcoholic fatty liver disease in which to study the mechanism of …