Coronaviruses (CoVs) are a group of single stranded RNA viruses, of which some of them
such as SARS-CoV, MERS-CoV, and SARS-CoV-2 are associated with deadly worldwide …

A growing amount of evidence indicates that the neuronally expressed developmentally
downregulated 4 (NEDD4, also known as NEDD4-1) E3 ligase plays a critical role in a …

The circadian rhythm is driven by a master clock within the suprachiasmatic nucleus which
regulates the rhythmic secretion of melatonin. Bmal1 coordinates the rhythmic expression of …

E3 ubiquitin ligases, an important part of ubiquitin proteasome system, catalyze the covalent
binding of ubiquitin to target substrates, which plays a role in protein ubiquitination and …

Abstract Phosphodiesterase 10A (PDE10A) hydrolyzes adenosine 3′, 5′-cyclic
monophosphate (cAMP) and guanosine 3′, 5′-cyclic monophosphate (cGMP). It is highly …

Hypoxia, low, non-physiological oxygen tension is a key regulator of tumor
microenvironment, determining the pathological tumor vascularization. Alleviation of hypoxia …

Transcriptomic analyses are commonly used to identify differentially expressed genes
between patients and controls, or within individuals across disease courses. These …

The endoplasmic reticulum (ER) is important to cells because of its essential functions,
including synthesizing three major nutrients and ion transport. When cellular homeostasis is …

The phosphodiesterase (PDE) superfamily comprises enzymes responsible for the cAMP
and cGMP degradation to AMP and GMP. PDEs are abundant in the brain, where they are …

Apart from its metabolic or physiological functions, melatonin has a potent cytoprotective
activity in the physiological and pathological conditions. It is synthetized by the pineal gland …