BACKGROUND The placenta is the active interface between mother and foetus, bearing the
molecular marks of rapid development and exposures in utero. The placenta is routinely …

Heme oxygenase (HO) isoforms catalyze the conversion of heme to carbon monoxide (CO)
and biliverdin with a concurrent release of iron, which can drive the synthesis of ferritin for …

Aberrant placentation generating placental oxidative stress is proposed to play a critical role
in the pathophysiology of preeclampsia. Unfortunately, therapeutic trials of antioxidants have …

Recent clinical studies indicate that an excess of angiostatic factors, such as soluble
endoglin (sEng), is related to the occurrence of preeclampsia. Although recent clinical …

Preeclampsia is a hypertensive disorder of pregnancy that affects 3–5% of all pregnancies.
There is evidence to suggest that epigenetic mechanisms, such as DNA methylation, play a …

Preeclampsia is a hypertensive disorder of pregnancy, classically defined as new-onset
hypertension and proteinuria of at least 300 mg in 24 h. It is among the most common …

Intrauterine growth restriction (IUGR) affects up to 10% of pregnancies in Western societies.
IUGR is a strong predictor of reduced short-term neonatal survival and impairs long-term …

Preeclampsia (PE) is one of the leading causes of maternal morbidity and mortality
worldwide. This disease is believed to occur in two stages with placental dysfunction in early …

Utero-placental development in pregnancy depends on direct maternal–fetal interaction in
the uterine wall decidua. Abnormal uterine vascular remodeling preceding placental …

Background Preeclampsia (PE) is a serious hypertensive pregnancy disorder with a
significant genetic component. Numerous genetic studies, including our own, have yielded …