Biosynthesis and applications of prenylquinones

M Kawamukai - Bioscience, biotechnology, and biochemistry, 2018 - academic.oup.com
Prenylquinones are isoprenoid compounds with a characteristic quinone structure and
isoprenyl tail that are ubiquitous in almost all living organisms. There are four major …

Prenylquinones in human parasitic protozoa: Biosynthesis, physiological functions, and potential as chemotherapeutic targets

IB Verdaguer, CA Zafra, M Crispim, RAC Sussmann… - Molecules, 2019 - mdpi.com
Human parasitic protozoa cause a large number of diseases worldwide and, for some of
these diseases, there are no effective treatments to date, and drug resistance has been …

A class C radical S‐adenosylmethionine methyltransferase synthesizes 8‐methylmenaquinone

S Hein, O Klimmek, M Polly, M Kern… - Molecular …, 2017 - Wiley Online Library
The membranous quinone/quinol pool is essential to the majority of life forms and has been
widely used as an important biomarker in microbial taxonomy. In the anaerobic world, the …

Biosynthesis and function of microbial methylmenaquinones

D Wilkens, J Simon - Advances in Microbial Physiology, 2023 - Elsevier
The membranous quinone/quinol pool is essential for the majority of life forms and its
composition has been widely used as a biomarker in microbial taxonomy. The most …

Exploring ubiquinone biosynthesis inhibition as a strategy for improving atovaquone efficacy in malaria

IB Verdaguer, M Crispim, CA Zafra… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
Atovaquone (AV) acts on the malaria parasite by competing with ubiquinol (UQH2) for its
union to the mitochondrial bc1 complex, preventing the ubiquinone-8 and ubiquinone-9 (UQ …

Presence of Phylloquinone in the Intraerythrocytic Stages of Plasmodium falciparum

RAC Sussmann, HB Gabriel, AG Ríos… - Frontiers in Cellular …, 2022 - frontiersin.org
Malaria is one of the most widespread parasitic diseases, especially in Africa, Southeast
Asia and South America. One of the greatest problems for control of the disease is the …