Respiratory syncytial virus (RSV) is a common cause of lower respiratory tract infections and
responsible for a large proportion of mortality in children and the elderly. There are no …

Disease‐causing microorganisms not only breach anatomical barriers and invade tissues
but also frequently enter host cells, nutrient‐enriched environments amenable to support …

Background The development of a fast and accurate, non-sputum-based point-of-care triage
test for tuberculosis (TB) would have a major impact on combating the TB burden worldwide …

Guanylate-binding proteins (GBP) are a family of dynamin-related large GTPases which are
expressed in response to interferons and other pro-inflammatory cytokines. GBPs mediate a …

Viral infection of different cell types induces a unique spectrum of host defence genes,
including interferon-stimulated genes (ISGs) and genes encoding other proteins with …

Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) infection is a leading
cause of pneumonia and death. The aim of this investigation is to identify the key genes in …

Guanylate binding proteins (GBPs) represent an evolutionary ancient protein family widely
distributed among eukaryotes. They are interferon (IFN)-inducible guanosine …

Background Non-sputum-based triage tests for tuberculosis are a priority for ending
tuberculosis. We aimed to evaluate the diagnostic accuracy of the late-prototype Xpert MTB …

NLRP3 inflammasome is implicated in the pathogenesis of inflammatory bowel diseases
(IBD). Since guanylate-binding protein 5 (GBP5) induces the NLRP3 inflammasome activity …

Background Sinomenine (SIN) is the main pharmacologically active component of
Sinomenii Caulis and protects against rheumatoid arthritis (RA). In recent years, many …