Nuclear receptor crosstalk can be defined as the interplay between different nuclear
receptors or between their overlapping signalling pathways. A subset of nuclear receptors …

Mineralocorticoid receptor antagonists (MRAs) are highly effective therapies for
cardiovascular and renal disease. However, the widespread clinical use of currently …

Peroxisome proliferator‐activated receptor alpha (PPARα, NR1C1) belongs to a large family
of ligand‐dependent nuclear receptors (NRs). It is one of the best studied NRs which …

Nuclear receptors (NRs) regulate cellular processes and serve as key targets in treating
metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis …

Many biological signaling pathways employ proteins that competitively dimerize in diverse
combinations. These dimerization networks can perform biochemical computations, in which …

Glucocorticoids (GCs) are widely used therapeutic agents to treat a broad range of
inflammatory conditions. Their functional effects are elicited by binding to the glucocorticoid …

The glucocorticoid receptor (GR) is a major nuclear receptor (NR) drug target for the
treatment of inflammatory disorders and several cancers. Despite the effectiveness of GR …

Exogenous glucocorticoids are widely used in the clinic for the treatment of inflammatory
disorders and auto-immune diseases. Unfortunately, their use is hampered by many side …

Monocyte activation plays an important role in diabetic complications such as diabetic
retinopathy (DR). However, the regulation of monocyte activation in diabetes remains …

The consequences of glucocorticoid receptor (GR) hypersensitivity during infection have so
far received little attention. We previously discovered that a natural gain-of-function …