[HTML][HTML] Developments in lung transplantation over the past decade

SC van der Mark, RAS Hoek… - European Respiratory …, 2020 - Eur Respiratory Soc
With an improved median survival of 6.2 years, lung transplantation has become an
increasingly acceptable treatment option for end-stage lung disease. Besides survival …

Organ preservation: from the past to the future

L Jing, L Yao, M Zhao, L Peng, M Liu - Acta Pharmacologica Sinica, 2018 - nature.com
Organ transplantation is the most effective therapy for patients with end-stage disease.
Preservation solutions and techniques are crucial for donor organ quality, which is directly …

Chronic lung allograft dysfunction: Definition, diagnostic criteria, and approaches to treatment―A consensus report from the Pulmonary Council of the ISHLT

GM Verleden, AR Glanville, ED Lease… - The Journal of Heart …, 2019 - jhltonline.org
The outcomes of transplantation vary widely by organ. Lung transplantation (LTx) has rather
poor long-term outcome, with a current median post-transplant survival of 6.0 years. 1, 2 …

Static lung storage at 10° C maintains mitochondrial health and preserves donor organ function

A Ali, A Wang, RVP Ribeiro, EL Beroncal… - Science Translational …, 2021 - science.org
Cold static preservation on ice (~ 4° C) remains the clinical standard of donor organ
preservation. However, mitochondrial injury develops during prolonged storage, which limits …

Cell death and ischemia-reperfusion injury in lung transplantation

M Capuzzimati, O Hough, M Liu - The Journal of Heart and Lung …, 2022 - Elsevier
Lung transplantation is the most effective therapy for patients with end-stage lung disease.
However, concern of donor lung damage and ischemia-reperfusion induced lung injury …

Long-term outcomes of lung transplant with ex vivo lung perfusion

C Divithotawela, M Cypel, T Martinu, LG Singer… - JAMA …, 2019 - jamanetwork.com
Importance The mortality rate for individuals on the wait list for lung transplant is 15% to
25%, and still only 20% of lungs from multiorgan donors are used for lung transplant. The …

Acute rejection after liver transplantation with machine perfusion versus static cold storage: a systematic review and meta-analysis

M Maspero, K Ali, B Cazzaniga, S Yilmaz, R Raj… - Hepatology, 2023 - journals.lww.com
Acute rejection after liver transplantation with machine per... : Hepatology Acute rejection after
liver transplantation with machine perfusion versus static cold storage: A systematic review and …

[HTML][HTML] Ex vivo lung perfusion

T Watanabe, M Cypel, S Keshavjee - Journal of thoracic disease, 2021 - ncbi.nlm.nih.gov
Lung transplantation is a life-saving treatment for patients with end stage lung disease. The
imbalance between lung graft supply and recipients has been a serious issue and barrier to …

De Novo DQ Donor-Specific Antibodies Are Associated with Chronic Lung Allograft Dysfunction after Lung Transplantation

JM Tikkanen, LG Singer, SJ Kim, Y Li… - American journal of …, 2016 - atsjournals.org
Rationale: Despite increasing evidence about the role of donor-specific human leukocyte
antigen (HLA) antibodies in transplant outcomes, the incidence and impact of de novo donor …

An observational study of Donor Ex Vivo Lung Perfusion in UK lung transplantation: DEVELOP-UK

A Fisher, A Andreasson, A Chrysos, J Lally… - Health Technology …, 2016 - eprints.gla.ac.uk
Background: Many patients awaiting lung transplantation die before a donor organ becomes
available. Ex vivo lung perfusion (EVLP) allows initially unusable donor lungs to be …