The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic
Abstract Fibroblast growth factor 21 (FGF21) is a stress-inducible hormone that has
important roles in regulating energy balance and glucose and lipid homeostasis through a …
important roles in regulating energy balance and glucose and lipid homeostasis through a …
Pharmacotherapy of obesity: available medications and drugs under investigation
Obesity is a chronic disease with a continuously rising prevalence that currently affects more
than half a billion people worldwide. Energy balance and appetite are highly regulated via …
than half a billion people worldwide. Energy balance and appetite are highly regulated via …
A dozen years of discovery: insights into the physiology and pharmacology of FGF21
SA Kliewer, DJ Mangelsdorf - Cell metabolism, 2019 - cell.com
It has been more than a dozen years since FGF21 burst on the metabolism field in a paper
showing that its pharmacologic administration caused weight loss and improved insulin …
showing that its pharmacologic administration caused weight loss and improved insulin …
Fibroblast growth factor–based pharmacotherapies for the treatment of obesity-related metabolic complications
The fibroblast growth factor (FGF) family, which comprises 22 structurally related proteins,
plays diverse roles in cell proliferation, differentiation, development, and metabolism. Among …
plays diverse roles in cell proliferation, differentiation, development, and metabolism. Among …
FGF19 and FGF21 for the treatment of NASH—two sides of the same coin? Differential and overlapping effects of FGF19 and FGF21 from mice to human
E Henriksson, B Andersen - Frontiers in Endocrinology, 2020 - frontiersin.org
FGF19 and FGF21 analogues are currently in clinical development for the potential
treatment of NASH. In Phase 2 clinical trials analogues of FGF19 and FGF21 decrease …
treatment of NASH. In Phase 2 clinical trials analogues of FGF19 and FGF21 decrease …
Antibody-mediated activation of the FGFR1/Klothoβ complex corrects metabolic dysfunction and alters food preference in obese humans
A Baruch, C Wong, LW Chinn, A Vaze… - Proceedings of the …, 2020 - National Acad Sciences
Fibroblast growth factor 21 (FGF21) controls metabolic organ homeostasis and
eating/drinking behavior via FGF receptor 1/Klothoβ (FGFR1/KLB) complexes expressed in …
eating/drinking behavior via FGF receptor 1/Klothoβ (FGFR1/KLB) complexes expressed in …
The role of adipokines in skeletal muscle inflammation and insulin sensitivity
T Nicholson, C Church, DJ Baker, SW Jones - Journal of Inflammation, 2018 - Springer
Background There is currently an unmet clinical need to develop better pharmacological
treatments to improve glucose handling in Type II Diabetes patients with obesity. To this end …
treatments to improve glucose handling in Type II Diabetes patients with obesity. To this end …
Is the use of artificial sweeteners beneficial for patients with diabetes mellitus? The advantages and disadvantages of artificial sweeteners
K Iizuka - Nutrients, 2022 - mdpi.com
Artificial sweeteners have been developed as substitutes for sugar. Sucralose, acesulfame K
(ACE K), aspartame, and saccharin are artificial sweeteners. Previously, artificial sweeteners …
(ACE K), aspartame, and saccharin are artificial sweeteners. Previously, artificial sweeteners …
[HTML][HTML] FGF19 and FGF21: In NASH we trust
S Talukdar, A Kharitonenkov - Molecular Metabolism, 2021 - Elsevier
Abstract Fibroblast Growth Factors 19 and 21 (FGF19 and FGF21) are novel endocrine
messengers that regulate multiple aspects of energy homeostasis. The magnitude and …
messengers that regulate multiple aspects of energy homeostasis. The magnitude and …
FGF21-receptor agonists: an emerging therapeutic class for obesity-related diseases
J Sonoda, MZ Chen, A Baruch - Hormone molecular biology and …, 2017 - degruyter.com
Abstract Fibroblast growth factor 21 (FGF21) analogs and FGF21 receptor agonists
(FGF21RAs) that mimic FGF21 ligand activity constitute the new “FGF21-class” of anti …
(FGF21RAs) that mimic FGF21 ligand activity constitute the new “FGF21-class” of anti …