Modulation of immunity by the secreted phospholipase A2 family

M Murakami, H Sato, Y Taketomi - Immunological reviews, 2023 - Wiley Online Library
Among the phospholipase A2 (PLA2) superfamily, which typically catalyzes the sn‐2
hydrolysis of phospholipids to yield fatty acids and lysophospholipids, the secreted PLA2 …

Extracellular vimentin amplifies inflammation: Perspectives for immune injury and therapeutics for periodontitis

Z Yuan, P Smith, CA McCulloch - The FASEB Journal, 2025 - Wiley Online Library
Periodontitis is an inflammatory disease triggered by microbial biofilms that promote immune
dysfunction and tissue destruction of tooth‐supporting tissues. The search for soluble …

An atlas of human vector-borne microbe interactions reveals pathogenicity mechanisms

TM Hart, ND Sonnert, X Tang, R Chaurasia, PE Allen… - Cell, 2024 - cell.com
Vector-borne diseases are a leading cause of death worldwide and pose a substantial
unmet medical need. Pathogens binding to host extracellular proteins (the" exoproteome") …

Group IIA secreted phospholipase A2 (PLA2G2A) augments adipose tissue thermogenesis

MS Kuefner, E Stephenson, M Savikj… - The FASEB …, 2021 - Wiley Online Library
Group IIA secreted phospholipase A2 (PLA2G2A) hydrolyzes glycerophospholipids at the sn‐
2 position resulting in the release of fatty acids and lysophospholipids. C57BL/6 mice do not …

Multimodal regulation of the osteoclastogenesis process by secreted group IIA phospholipase A2

M Mangini, R D'angelo, C Vinciguerra… - Frontiers in Cell and …, 2022 - frontiersin.org
Increasing evidence points to the involvement of group IIA secreted phospholipase A2
(sPLA2-IIA) in pathologies characterized by abnormal osteoclast bone-resorption activity …