How the shape of embryos and organs emerges during development is a fundamental
question that has fascinated scientists for centuries. Tissue dynamics arise from a small set …

Identifying and validating molecular targets of interventions that extend the human health
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …

The segmented body plan of vertebrates is established during somitogenesis, a well-studied
process in model organisms; however, the details of this process in humans remain largely …

INTRODUCTION Vertebrate development comprises multiple complex morphogenetic
processes that shape the embryonic body plan through self-organization of pluripotent stem …

Canonical WNT/β-catenin signaling is involved in most of the mechanisms that lead to the
formation and development of cancer cells. It plays a central role in three cyclic processes …

Patterns are ubiquitous in living systems and underlie the dynamic organization of cells,
tissues, and embryos. Mathematical frameworks have been devised to account for the self …

Zebrafish (Danio rerio) are a small‐bodied tropical, freshwater fish species originally from
South Asia. The ease of care, year‐round prolific breeding, and transparent, external …

Combining concepts from topology and algorithms, this book delivers what its title promises:
an introduction to the field of computational topology. Starting with motivating problems in …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

A small number of signalling pathways are used iteratively to regulate cell fates, cell
proliferation and cell death in development. Notch is the receptor in one such pathway, and …