Quality control of the mitochondrial proteome

J Song, JM Herrmann, T Becker - Nature Reviews Molecular Cell …, 2021 - nature.com
Abstract Mitochondria contain about 1,000–1,500 proteins that fulfil multiple functions.
Mitochondrial proteins originate from two genomes: mitochondrial and nuclear. Hence …

Mechanisms and regulation of protein synthesis in mitochondria

E Kummer, N Ban - Nature Reviews Molecular Cell Biology, 2021 - nature.com
Mitochondria are cellular organelles responsible for generation of chemical energy in the
process called oxidative phosphorylation. They originate from a bacterial ancestor and …

Synchronized mitochondrial and cytosolic translation programs

MT Couvillion, IC Soto, G Shipkovenska… - Nature, 2016 - nature.com
Oxidative phosphorylation (OXPHOS) is a vital process for energy generation, and is carried
out by complexes within the mitochondria. OXPHOS complexes pose a unique challenge for …

Mitochondrial biogenesis and mitochondrial reactive oxygen species (ROS): a complex relationship regulated by the cAMP/PKA signaling pathway

C Bouchez, A Devin - Cells, 2019 - mdpi.com
Mitochondrial biogenesis is a complex process. It requires the contribution of both the
nuclear and the mitochondrial genomes and therefore cross talk between the nucleus and …

Plant organellar RNA maturation

I Small, J Melonek, AV Bohne, J Nickelsen… - The Plant …, 2023 - academic.oup.com
Plant organellar RNA metabolism is run by a multitude of nucleus-encoded RNA-binding
proteins (RBPs) that control RNA stability, processing, and degradation. In chloroplasts and …

Structure of the yeast mitochondrial large ribosomal subunit

A Amunts, A Brown, X Bai, JL Llácer, T Hussain… - Science, 2014 - science.org
Mitochondria have specialized ribosomes that have diverged from their bacterial and
cytoplasmic counterparts. We have solved the structure of the yeast mitoribosomal large …

Structural basis of mitochondrial translation

S Aibara, V Singh, A Modelska, A Amunts - elife, 2020 - elifesciences.org
Translation of mitochondrial messenger RNA (mt-mRNA) is performed by distinct
mitoribosomes comprising at least 36 mitochondria-specific proteins. How these …

Structure and function of the mitochondrial ribosome

BJ Greber, N Ban - Annual review of biochemistry, 2016 - annualreviews.org
Mitochondrial ribosomes (mitoribosomes) perform protein synthesis inside mitochondria, the
organelles responsible for energy conversion and adenosine triphosphate production in …

The structure of the yeast mitochondrial ribosome

N Desai, A Brown, A Amunts, V Ramakrishnan - Science, 2017 - science.org
Mitochondria have specialized ribosomes (mitoribosomes) dedicated to the expression of
the genetic information encoded by their genomes. Here, using electron cryomicroscopy, we …

Mitochondrial protein synthesis adapts to influx of nuclear-encoded protein

R Richter-Dennerlein, S Oeljeklaus, I Lorenzi… - Cell, 2016 - cell.com
Mitochondrial ribosomes translate membrane integral core subunits of the oxidative
phosphorylation system encoded by mtDNA. These translation products associate with …