Background: Diffuse Intrinsic Pontine Glioma (DIPG) is the leading cause of brain tumor-
related death in children, with median survival of less than one year. Despite decades of …

Simple Summary Diffuse midline gliomas (DMGs) remain one of the most devastating
childhood brain tumour types, for which there is currently no known cure. In this review we …

Glioblastomas exhibit widespread molecular alterations including a highly distorted
epigenome. Here, we resolve genome-wide 5-methylcytosine and 5-hydroxymethylcytosine …

Cell populations with differing proliferative, stem-like and tumorigenic states co-exist in most
tumors and especially malignant gliomas. Whether metabolic variations can drive this …

NOTCH regulates stem cells during normal development and stemlike cells in cancer, but
the roles of NOTCH in the lethal pediatric brain tumor diffuse intrinsic pontine glioma (DIPG) …

Wingless (Wnt) signaling is an important pathway in gliomagenesis and in the growth of
stem-like glioma cells. Using immunohistochemistry to assess the translocation of β-catenin …

Simple Summary Diffuse midline glioma (DMG) is a devastating pediatric brain tumor with
urgent unmet need for novel treatment modalities. LIN28B RNA binding protein is …

The discovery of TET-mediated DNA hydroxymethylation as a mechanism of DNA
demethylation, along with the observation of disrupted hydroxymethylation patterns in …

Gliomas represent the most common primary intraparenchymal tumors of the central
nervous system in adults and children and are a genetic and phenotypic heterogeneous …

A level of epigenetic programming, encoded by complex sets of chemical marks on DNA
and histones, and by context-specific DNA, RNA, protein interactions, that all regulate the …