Leptin as a key regulator of the adipose organ

C Picó, M Palou, CA Pomar, AM Rodríguez… - Reviews in Endocrine …, 2022 - Springer
Leptin is a hormone primarily produced by the adipose tissue in proportion to the size of fat
stores, with a primary function in the control of lipid reserves. Besides adipose tissue, leptin …

Leptin resistance and diet-induced obesity: central and peripheral actions of leptin

N Sáinz, J Barrenetxe, MJ Moreno-Aliaga, JA Martínez - Metabolism, 2015 - Elsevier
Obesity is a chronic disease that represents one of the most serious global health burdens
associated to an excess of body fat resulting from an imbalance between energy intake and …

Epigenetics and the embodiment of race: developmental origins of US racial disparities in cardiovascular health

CW Kuzawa, E Sweet - … Journal of Human Biology: The Official …, 2009 - Wiley Online Library
The relative contribution of genetic and environmental influences to the US black‐white
disparity in cardiovascular disease (CVD) is hotly debated within the public health …

Developmental programming in response to maternal overnutrition

MZ Alfaradhi, SE Ozanne - Frontiers in genetics, 2011 - frontiersin.org
Metabolic disorders have seen an increased prevalence in recent years in developed as
well as developing countries. While it is clear lifestyle choices and habits have contributed to …

Obesity and gestational diabetes independently and collectively induce specific effects on placental structure, inflammation and endocrine function in a cohort of South …

E Musa, E Salazar‐Petres, A Arowolo… - The Journal of …, 2023 - Wiley Online Library
Maternal obesity and gestational diabetes mellitus (GDM) are associated with insulin
resistance and health risks for mother and offspring. Obesity is also characterized by low …

Lactation as a programming window for metabolic syndrome

C Picó, F Reis, C Egas, P Mathias… - European Journal of …, 2021 - Wiley Online Library
The concept of developmental origins of health and disease (DOHaD) was initially
supported by the low birth weight and higher risk of developing cardiovascular disease in …

Mechanisms underlying the association between breastfeeding and obesity

CJ Bartok, AK Ventura - International Journal of Pediatric Obesity, 2009 - Taylor & Francis
Decades of epidemiological research have established that breastfeeding is associated with
a modest reduction in risk of later overweight and obesity. However, no systematic effort has …

A narrative review of the associations between six bioactive components in breast milk and infant adiposity

DA Fields, CR Schneider, G Pavela - Obesity, 2016 - Wiley Online Library
Objective This narrative review examines six important non‐nutritive substances in breast
milk, many of which were thought to have little to no biological significance. The overall …

Metabolic imprinting, programming and epigenetics–a review of present priorities and future opportunities

B Hanley, J Dijane, M Fewtrell, A Grynberg… - British journal of …, 2010 - cambridge.org
Metabolic programming and metabolic imprinting describe early life events, which impact
upon on later physiological outcomes. Despite the increasing numbers of papers and …

[PDF][PDF] Adverse effects of nutritional programming during prenatal and early postnatal life, some aspects of regulation and potential prevention and treatments

P Guilloteau, R Zabielski, HM Hammon… - J Physiol …, 2009 - academia.edu
Nutritional programming, regulation and some ways for prevention/treatment to ameliorate
or normalize adverse outcomes of programming are discussed. Epidemiological studies in …