Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

In the past few years, cancer immunotherapy has emerged as a safe and effective
alternative for treatment of cancers that do not respond to classical treatments, including …

The ability of the immune system to identify and destroy nascent tumors, and to thereby
function as a primary defense against cancer, has been debated for many decades. Recent …

Cellular transformation and tumor development result from an accumulation of mutational
and epigenetic changes that alter normal cell growth and survival pathways. For the last 100 …

Triggering of tumour cell apoptosis is the foundation of many cancer therapies. Death
receptors of the tumour necrosis factor (TNF) superfamily have been largely characterized …

Apoptosis ligand 2 tumor necrosis factor (TNF)-related apoptosis-inducing ligand
(Apo2L/TRAIL) belongs to a small subset of proapoptotic protein ligands in the TNF …

The members of the tumour necrosis factor (TNF) superfamily of cytokines play important
roles in the regulation of various immune‐cell functions. Likewise, induction of cell death by …

Deletions of chromosome 8p are a recurrent event in B-cell non-Hodgkin lymphoma (B-
NHL), suggesting the presence of a tumor suppressor gene. We have characterized these …

Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL/TNFSF10) and Fas
Ligand (FasL/TNFSF6), two major cytokines of the TNF (Tumor Necrosis Factor) superfamily …

Preclinical data support the potential of the death-signaling receptors for TRAIL as targets for
cancer therapy. However, it is unclear whether these death-signaling receptors suppress the …