Bioengineering strategies for restoring vision
Late-stage retinal degenerative disease involving photoreceptor loss can be treated by
optogenetic therapy, cell transplantation and retinal prostheses. These approaches aim to …
optogenetic therapy, cell transplantation and retinal prostheses. These approaches aim to …
Retinoic acid signaling in development and differentiation commitment and its regulatory topology
D Wu, FA Khan, K Zhang, NS Pandupuspitasari… - Chemico-Biological …, 2024 - Elsevier
Retinoic acid (RA), the derivative of vitamin A/retinol, is a signaling molecule with important
implications in health and disease. It is a well-known developmental morphogen that …
implications in health and disease. It is a well-known developmental morphogen that …
Revival of light signalling in the postmortem mouse and human retina
Death is defined as the irreversible cessation of circulatory, respiratory or brain activity.
Many peripheral human organs can be transplanted from deceased donors using protocols …
Many peripheral human organs can be transplanted from deceased donors using protocols …
Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates
Vision restoration is an ideal medical application for optogenetics, because the eye provides
direct optical access to the retina for stimulation. Optogenetic therapy could be used for …
direct optical access to the retina for stimulation. Optogenetic therapy could be used for …
Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease
H Leinonen, NC Pham, T Boyd, J Santoso… - Elife, 2020 - elifesciences.org
Neuronal plasticity of the inner retina has been observed in response to photoreceptor
degeneration. Typically, this phenomenon has been considered maladaptive and may …
degeneration. Typically, this phenomenon has been considered maladaptive and may …
Retinoic acid inhibitors mitigate vision loss in a mouse model of retinal degeneration
Rod and cone photoreceptors degenerate in retinitis pigmentosa (RP). While downstream
neurons survive, they undergo physiological changes, including accelerated spontaneous …
neurons survive, they undergo physiological changes, including accelerated spontaneous …
Artificial intelligence techniques for retinal prostheses: A comprehensive review and future direction
Objective. Retinal prostheses are promising devices to restore vision for patients with severe
age-related macular degeneration or retinitis pigmentosa disease. The visual processing …
age-related macular degeneration or retinitis pigmentosa disease. The visual processing …
[HTML][HTML] High-density optical coherence tomography analysis provides insights into early/intermediate age-related macular degeneration retinal layer changes
Purpose: To topographically map all of the thickness differences in individual retinal layers
between early/intermediate age-related macular degeneration (AMD early/AMD int) and …
between early/intermediate age-related macular degeneration (AMD early/AMD int) and …
Immunological consequences of compromised ocular immune privilege accelerate retinal degeneration in retinitis pigmentosa
Background Retinitis pigmentosa (RP) is a hereditary retinal disease which leads to visual
impairment. The onset and progression of RP has physiological consequences that affects …
impairment. The onset and progression of RP has physiological consequences that affects …
Molecular basis of retinal remodeling in a zebrafish model of retinitis pigmentosa
A hallmark of inherited retinal degenerative diseases such as retinitis pigmentosa (RP) is
progressive structural and functional remodeling of the remaining retinal cells as …
progressive structural and functional remodeling of the remaining retinal cells as …