[HTML][HTML] Non-canonical G protein signaling

B Nürnberg, S Beer-Hammer, E Reisinger… - Pharmacology & …, 2024 - Elsevier
The original paradigm of classical-also referred to as canonical-cellular signal transduction
of heterotrimeric G proteins (G protein) is defined by a hierarchical, orthograde interaction of …

[HTML][HTML] Class A and C GPCR dimers in neurodegenerative diseases

AB Caniceiro, B Bueschbell, AC Schiedel… - Current …, 2022 - ncbi.nlm.nih.gov
Neurodegenerative diseases affect over 30 million people worldwide with an ascending
trend. Most individuals suffering from these irreversible brain damages belong to the elderly …

[HTML][HTML] Inhibitory effect of truncated isoforms on GPCR dimerization predicted by combinatorial computational strategy

M Li, R Qing, F Tao, P Xu, S Zhang - Computational and Structural …, 2024 - Elsevier
G protein-coupled receptors (GPCRs) play a pivotal role in fundamental biological
processes and disease development. GPCR isoforms, derived from alternative splicing, can …

The role of dopamine receptor dimer complexes in the pathogenesis of depression

AA Gerasimov, OV Smirnova - Journal of Evolutionary Biochemistry and …, 2024 - Springer
In this review, we address the oligomerization of G protein-coupled receptors (GPCRs),
which significantly expands the functional capabilities of cells in living organisms by …

[PDF][PDF] CHARACTERIZATION OF PROTEIN-PROTEIN INTERACTIONS INVOLVING G PROTEIN-COUPLED RECEPTOR 143 BY COMPUTATIONAL AND …

I de Sousa Moreira - 2023 - estudogeral.uc.pt
Os recetores acoplados à proteína G (GPCRs) desempenham funções críticas no
desenvolvimento e progressão de diversas patologias. Muitos membros da família GPCR …