Network medicine is an emerging area of research dealing with molecular and genetic
interactions, network biomarkers of disease, and therapeutic target discovery. Large-scale …

Myxomatous mitral valve degeneration (MMVD) is a leading cause of valve repair or
replacement secondary to the production of mitral regurgitation, cardiac enlargement …

Background: Myocardial infarction (MI) induces an intense injury response that ultimately
generates a collagen-dominated scar. Although required to prevent ventricular rupture, the …

Degenerative mitral valve (MV) regurgitation (MR) is a highly prevalent heart disease that
requires surgery in severe cases. Here, we show that a decrease in the activity of the …

Toxicity is a major cause of attrition in the development of pharmaceuticals, and the off-target
effects are a frequent contributor. The 5-HT2B receptor agonism is known to be responsible …

The mitral valve is a complex multilayered structure populated by fibroblast-like cells,
valvular interstitial cells (VIC) which are embedded in an extracellular matrix (ECM) scaffold …

Carcinoid heart disease (CHD) is a paraneoplastic cardiac manifestation occurring in
patients with carcinoid syndrome (CS) and advanced neuroendocrine malignancy. In about …

Cardiovascular diseases (CVD) are diverse disorders affecting the heart and vasculature in
millions of people worldwide. Like other fields, CVD research has benefitted from the deluge …

Background TGFβ signaling appears to contribute to the pathogenesis of myxomatous mitral
valve disease (MMVD) in both dogs and humans. However, little is known about the extent …

Heart valve disease (HVD) is a complex entity made by different pathological processes that
ultimately lead to the abnormal structure and disorganization of extracellular matrix proteins …