Bioactive sphingolipids as emerging targets for signal transduction in cancer development

W Jia, J Yuan, J Zhang, S Li, W Lin, B Cheng - Biochimica et Biophysica …, 2024 - Elsevier
Sphingolipids, crucial components of cellular membranes, play a vital role in maintaining
cellular structure and signaling integrity. Disruptions in sphingolipid metabolism are …

The effect of cholesterol in MCF7 human breast cancer cells

E Albi, M Mandarano, S Cataldi, MR Ceccarini… - International Journal of …, 2023 - mdpi.com
In the last decade, cholesterol level has been implicated in several types of cancer,
including breast cancer. In the current study, we aimed to investigate the condition of lipid …

Monitoring concentration and lipid signature of plasma extracellular vesicles from HR+ metastatic breast cancer patients under CDK4/6 inhibitors treatment

M Richard, R Moreau, M Croyal… - Journal of …, 2024 - Wiley Online Library
Extracellular vesicles (EVs) are cell‐derived small membrane structures that transport
various molecules. They have emerged as potential circulating biomarkers for monitoring …

Sphingomyelin Metabolism Modifies Luminal A Breast Cancer Cell Line under a High Dose of Vitamin C

M Codini, F Fiorani, M Mandarano, S Cataldi… - International Journal of …, 2023 - mdpi.com
The role of sphingomyelin metabolism and vitamin C in cancer has been widely described
with conflicting results ranging from a total absence of effect to possible preventive and/or …

Vitamin C Modifies the Phenotype of Hormone Receptor Positive/HER2 Negative Breast Cancer Cells and Induces Changes in Sphingolipid Metabolism

M Codini, F Fiorani, M Mandarano, S Cataldi, C Arcuri… - 2023 - preprints.org
The effect of the antioxidant vitamin C in cancer has been studied for over 30 years with
conflict-ing results ranging from total absence of effect, to possible protective effect, to …