The comet assay is a versatile, reliable, cost-efficient, and fast technique for detecting DNA
damage and repair in any tissue. It is useable in almost any cell type and applicable to both …

The in vivo working group (WG) considered three topics: acceptable maximum doses for
negative erythrocyte micronucleus (MN) tests, validation status of MN assays in non …

As a part of the 6th IWGT, an expert working group on the comet assay evaluated critical
topics related to the use of the in vivo comet assay in regulatory genotoxicity testing. The …

The phosphorylation of histone H2AX in Serine 139 (gamma‐H2AX) marks regions of DNA
double strand breaks and contributes to the recruitment of DNA repair factors to the site of …

DNA damage plays a pivotal role in carcinogenesis and other diseases. The comet assay
has been used for more than three decades to measure DNA damages. The 1–2 gels/slide …

The in vivo comet assay is usually performed in fresh tissues by processing cells
immediately after collection, an approach that is not always possible from a logistical point of …

The comet assay is gaining popularity as a means to assess DNA damage in cultured cells
and tissues, particularly following exposure to chemicals or other environmental stressors …

The comet assay is one of the standard tests for evaluating the genotoxic potential of a test
item able to detect DNA strand breaks in cells or isolated nuclei from various tissues. The in …

To compare the extent of potential inter‐laboratory variability and the influence of different
comet image analysis systems, in vivo comet experiments were conducted using the …

In genotoxicity testing of pharmaceuticals the rodent alkaline comet assay is being
increasingly used as a second in vivo assay in addition to the in vivo micronucleus assay to …