An overview of the safety and biological effects of Bacillus thuringiensis Cry toxins in mammals

N Rubio‐Infante… - Journal of applied …, 2016 - Wiley Online Library
Crystal proteins (Cry) produced during the growth and sporulation phases of Bacillus
thuringiensis (Bt) bacterium are known as delta endotoxins. These toxins are being used …

Case studies on genetically modified organisms (GMOs): Potential risk scenarios and associated health indicators

B De Santis, N Stockhofe, JM Wal… - Food and Chemical …, 2018 - Elsevier
Within the frame of the EU-funded MARLON project, background data were reviewed to
explore the possibility of measuring health indicators during post-market monitoring for …

[HTML][HTML] Acidosis differently modulates the inflammatory program in monocytes and macrophages

A Riemann, H Wußling, H Loppnow, H Fu… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Inflammation, ischemia or the microenvironment of solid tumors is often accompanied by a
reduction of extracellular pH (acidosis) that stresses the cells and acts on cellular signaling …

Synovial macrophages: Past life, current situation, and application in inflammatory arthritis

LK Bai, YZ Su, XX Wang, B Bai, CQ Zhang… - Frontiers in …, 2022 - frontiersin.org
Inflammatory arthritis is an inflammatory disease that involves the joints and surrounding
tissues. Synovial hyperplasia often presents when joints become inflamed due to immune …

Cry1Ac toxin induces macrophage activation via ERK1/2, JNK and p38 mitogen-activated protein kinases

M Torres-Martínez, N Rubio-Infante… - The international journal …, 2016 - Elsevier
Abstract The Cry1Ac toxin from Bacillus thuringiensis is used commercially as a bio-
insecticide and is expressed in transgenic plants that are used for human and animal …

Structure characterization of three polysaccharides and a comparative study of their immunomodulatory activities on chicken macrophage

W Fan, S Zhang, P Hao, P Zheng, J Liu, X Zhao - Carbohydrate polymers, 2016 - Elsevier
In this study, we evaluated structure characterization and immunomodulatory activity of
polysaccharides from Astragalus aboriginum Richardson (RAPS), Atractylodes …

Literature review in support of adjuvanticity/immunogenicity assessment of proteins

MD Parenti, A Santoro, A Del Rio… - EFSA Supporting …, 2019 - Wiley Online Library
Based on the risk assessment of genetically modified plants, according to Implementing
Regulation (EU) No 503/201321 “In cases when known functional aspects of the newly …

Therapy with multi-epitope virus-like particles of B19 parvovirus reduce tumor growth and lung metastasis in an aggressive breast cancer mouse model

A de Jesus Jimenez-Chavez, L Moreno-Fierros… - Vaccine, 2019 - Elsevier
Triple-negative breast cancer is a major health problem that lacks molecular targets for
therapy. Neoepitopes represent a viable option to induce antitumor immune responses, but …

The Macrophage Activation Induced by Bacillus thuringiensis Cry1Ac Protoxin Involves ERK1/2 and p38 Pathways and the Interaction with Cell‐Surface‐HSP70

N Rubio‐Infante, D Ilhuicatzi‐Alvarado… - Journal of cellular …, 2018 - Wiley Online Library
Here, we aimed to further characterize the mechanisms involved in protoxin (p) Cry1Ac‐
induced macrophage activation. We demonstrated that pCry1Ac induces MAPK ERK1/2 …

Analysis of immunostimulatory activity of polysaccharide extracted from Yu-Ping-Feng in vitro and in vivo

W Fan, P Zheng, Y Wang, P Hao, J Liu… - Biomedicine & …, 2017 - Elsevier
As a traditional Chinese multiherbal formula, Yu-Ping-Feng (YPF) is frequently used to treat
cold, flu and inflammation-associated diseases. We aimed to evaluate the …