ATP-binding cassette (ABC) superfamily comprises a large group of ubiquitous
transmembrane proteins that play a crucial role in transporting a diverse spectrum of …

Candida albicans is an important human pathogenic yeast, that can become resistant to
commonly used antifungal agents, such as azoles. One mechanism of drug resistance is …

Among the several mechanisms of multidrug resistance (MDR), overexpression of drug
efflux pumps CaCdr1p and CaMdr1p belonging to ATP binding cassette (ABC) and major …

ABC transporters of the Pleiotropic Drug Resistance (PDR) family are the main actors of
antifungal resistance in pathogenic fungi. While their involvement in clinical resistant strains …

Drug resistance mechanisms in human pathogenic Candida species are continually
evolving. Over the time, Candida species have acquired diverse strategies to vanquish the …

Multidrug resistance (MDR) transporters belonging to either the ATP-Binding Cassette
(ABC) or Major Facilitator Superfamily (MFS) groups are major determinants of clinical drug …

ATP-binding cassette (ABC) superfamily comprises membrane transporters that power the
active transport of substrates across biological membranes. These proteins harness the …

G-protein-coupled receptors (GPCRs) are the largest family of transmembrane receptors in
fungi. These receptors have an important role in the transduction of extracellular signals into …

Drug resistance mechanisms in human pathogenic Candida species are constantly
evolving. Over time, these species have developed diverse strategies to counter the effects …

The pleiotropic drug resistance transporter Cdr1 from Candida albicans plays a crucial role
in antifungal resistance. Here, we present high-resolution cryo-electron microscopy …