Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …

Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

Objectives Chronic and high consumption of fat constitutes an environmental stress that
leads to metabolic diseases. We hypothesized that high-fat diet (HFD) transgenerationally …

BACKGROUND Spermatozoa are highly differentiated, transcriptionally inert cells
characterized by a compact nucleus with minimal cytoplasm. Nevertheless they contain a …

BACKGROUND There has been substantial interest in assessing whether RNAs (mRNAs
and sncRNAs, ie small non-coding) delivered from mammalian spermatozoa play a …

Retrotransposons, mainly LINEs, SINEs, and endogenous retroviruses, make up roughly
40% of the mammalian genome and have played an important role in genome evolution …

Background RNA interference (RNAi) is a highly conserved cellular mechanism. In some
organisms, such as Caenorhabditis elegans, the RNAi response can be transmitted …

Chromosomal translocations are a hallmark of leukemia/lymphoma and also appear in solid
tumors, but the underlying mechanism remains elusive. By establishing a cellular model that …

Planarians are members of the Platyhelminthes (flatworms). These animals have evolved a
remarkable stem cell system. A single pluripotent adult stem cell type (“neoblast”) gives rise …

Piwi-interacting RNAs (piRNAs) silence transposons and maintain genome integrity during
germline development. In Drosophila, transposon-rich heterochromatic clusters encode …